雷贝拉唑联合莫沙必利治疗老年反流性食管炎患者的效果及其对胃肠激素水平、LES功能及血清炎症因子的影响

The effect of rabeprazole combined with mosapride in the treatment of elderly patients with reflux esophagitis and its influence on gastrointestinal hormone levels, LES function and serum inflammatory factors

目的探究雷贝拉唑联合莫沙必利治疗老年反流性食管炎患者的效果及其对胃肠激素水平、食管下括约肌(LES)功能及血清炎症因子的影响。方法选取我科127例老年反流性食管炎患者,根据随机数字表法分组。对照组63例给予雷贝拉唑联合吗丁啉的治疗,观察组64例采用雷贝拉唑联合莫沙必利治疗,对比疗效。结果治疗后观察组总有效率、胃泌素、胃动素、LES压力、pH值(LES以上5cm)水平高于对照组,IL-17、IL-23低于对照组,有统计学意义(P<0.05)。结论雷贝拉唑联合莫沙必利老年反流性食管炎患者治疗,可有效降低炎症反应,提高胃肠激素水平和LES功能,提升临床疗效。

Objective To explore the effect of rabeprazole combined with mosapride in the treatment of elderly patients with reflux esophagitis and its influence on gastrointestinal hormone level, lower esophageal sphincter(LES)function and serum inflammatory factors.Methods 127 elderly patients with reflux esophagitis were selected and divided into groups according to random number table.63 cases in the control group were given rabeprazole combined with domperidone, and 64 cases in the observation group were treated with rabeprazole combined with Mosapride, and the curative effect was compared.Results After treatment, the total effective rate, gastrin, motilin, LES pressure and pH value(5 cm above LES)in the observation group were higher than those in the control group, while the levels of IL-17 and IL-23 in the observation group were lower than those in the control group(P<0.05).Conclusion Rabeprazole combined with mosapride in the treatment of elderly patients with reflux esophagitis can effectively reduce the inflammatory reaction, improve the gastrointestinal hormone level and Les function, and improve the clinical efficacy.