卡泊三醇软膏对慢性湿疹患者皮损及皮肤生理功能的影响

Effects of calcipotriol ointment on skin lesions and skin physiological functions of patients with chronic eczema

目的探讨卡泊三醇软膏对慢性湿疹患者皮损及皮肤生理功能的影响。方法选取2019年3月-2020年3月期间收治的慢性湿疹患者92例,按随机平行对照法分为两组,对照组46例给予地奈德乳膏治疗,观察组46例加用卡泊三醇软膏治疗,8周后对比两组皮损、皮肤生理功能和不良反应发生率。结果两组治疗前皮损指标相比无统计学意义(P>0.05);两组治疗后皮损指标均优于治疗前,观察组优于对照组(P<0.05)。两组治疗前皮肤生理功能指标相比无统计学意义(P>0.05);两组治疗后皮肤生理功能指标均优于治疗前,观察组优于对照组(P<0.05);观察组不良反应发生率为6.52%,对照组不良反应发生率为21.74%(P<0.05)。结论卡泊三醇软膏治疗慢性湿疹临床效果显著,可以明显缓解患者皮损,改善患者的皮肤功能,且不良反应发生率低。

Objective To investigate the effects of capotril ointment on skin lesions and skin physiological functions in patients with chronic eczema.Methods A total of 92 patients with chronic eczema admitted from March 2019 to March 2020 were selected and divided into two groups according to the randomized parallel control method.46 patients in the control group were treated with Deside cream, while 46 patients in the observation group were treated with capparitol ointment.After 8 weeks, the skin lesions, skin physiological functions and adverse reaction rates of the two groups were compared.Results There was no statistically significant difference between the two groups before treatment(P>0.05).The skin lesion indexes after treatment were better in both groups than before treatment, and the observation group was better than the control group(P<0.05).There was no statistically significant difference in skin physiological function between the two groups before treatment(P>0.05).After treatment, the skin physiological function indexes of both groups were better than those of the control group(P<0.05).The incidence of adverse reactions was 6.52% in the observation group and 21.74% in the control group(P<0.05).Conclusion Capotriol ointment is effective in treating chronic eczema.It can relieve skin lesions and improve skin function, and the incidence of adverse reactions is low.