八子补肾胶囊的抗衰老研究进展

Bazi Bushen Capsules on Anti-aging:A Review

衰老导致的机体功能减退和老年性疾病严重影响人类的健康与寿命,是生命科学领域的重大课题。气络学说精气神理论指导研发的八子补肾胶囊是补精益气抗衰老的代表性中成药,既往药理和临床研究证实,该制剂具有抗衰老及防治衰老相关疾病的综合优势。其中,药理研究显示,八子补肾胶囊能够改善小鼠外观状态,提高性激素水平,抑制动脉粥样硬化形成,改善心功能;提高学习记忆认知能力,改善神经功能;改善骨质疏松和肌肉功能;提高精子数量和质量;其机制与上调沉默调节蛋白6(SIRT6)水平、下调衰老相关蛋白p53和p16水平、上调端粒酶逆转录酶水平、减轻炎症和氧化反应有关。临床研究证实其能够改善肾精亏虚患者症状表现,提高运动能力,改善阳痿患者性功能。基于气络学说的八子补肾胶囊抗衰老研究充分体现了“理论-新药-实验-临床”相结合的中医学术创新与转化新模式,为中医药抗衰老研究做出了示范。

The decline of body function and senile diseases caused by aging seriously affect human health and life span,which is an important topic in the field of life science.Bazi Bushen capsules is a representative Chinese patent medicine for tonifying essence,invigorating Qi and anti-aging,guided by Qiluo doctrine,and essence,Qi and spirit theory.Previous pharmacological and clinical studies have confirmed that this preparation has the comprehensive advantages of anti-aging,and prevention and treatment of aging-related diseases.Among them,pharmacological studies showed that Bazi Bushen capsules had the effect of improving the appearance status of mice,improving the level of sex hormones,inhibiting the formation of atherosclerosis,improving cardiac function,improving learning and memory cognitive ability,improving neurological function improving osteoporosis and muscle function,improving sperm count and quality.The mechanism was related to the up-regulation of the recombinant sirtuin(SIRT6)level,down-regulation of the levels of aging-related proteins p53 and p16,up-regulation of telomerase reverse transcriptase level,and alleviation of inflammation and oxidative response.Clinical studies have proved that it can improve the symptoms of patients with kidney essence deficiency,improve exercise ability,and improve the sexual function of impotence patients.Anti-aging research of Bazi Bushen capsules based on Qiluo doctrine fully embodies the new mode of academic innovation and transformation of traditional Chinese medicine(TCM)with the combination of"theory-new drugexperiment-clinic",which has made a demonstration for the anti-aging research of TCM.