血清let-7a水平对喉癌手术患者预后的预测价值

Predictive value of serum let-7a level on the prognosis of patients receiving laryngeal cancer surgery

目的探讨血清let-7a水平对喉癌手术患者预后的预测价值。方法根据术后3年内是否死亡将85例接受手术治疗的喉癌患者分为死亡组(n=21)和生存组(n=64)。采用实时荧光定量聚合酶链反应检测血清let-7a水平,采用Logistic回归模型分析喉癌手术患者预后的影响因素,采用受试者工作特征(ROC)曲线分析let-7a对喉癌手术患者预后的预测价值。结果随访3年内,共21例(24.71%)患者死亡。死亡组和生存组患者的肿瘤类型、分化程度、T分期、TNM分期及let-7a水平比较,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,肿瘤类型、分化程度、T分期、TNM分期及let-7a水平均是喉癌手术患者预后的独立影响因素(P﹤0.05)。ROC曲线分析结果显示,血清let-7a水平预测喉癌手术患者预后的曲线下面积为0.923,截断值为0.66,灵敏度为85.70%,特异度为84.40%。结论血清let-7a是喉癌手术患者预后的独立预测因子,对预测喉癌手术患者预后具有重要意义。

Objective To investigate the predictive value of serum let-7a level on the prognosis of patients receiving laryngeal cancer surgery.Method A total of 85 patients with laryngeal cancer who underwent surgery were divided into death group(n=21)and survival group(n=64)according to their survival within 3 years after the surgery.Serum level of let-7a was detected by quantitative real-time polymerase chain reaction.The Logistic regression model was used to ana-lyze the prognostic factors of patients receiving laryngeal cancer surgery.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of let-7a on the prognosis of patients receiving laryngeal cancer surgery.Result During 3-years follow-up,a total of 21(24.71%)patients were died.There were significant differences in tumor type,degree of differentiation,T stage,TNM stage,and let-7a level between the death group and the survival group(P<0.05).Logistic regression analysis indicated that tumor type,degree of differentiation,T stage,TNM stage,and let-7a lev-el were independent prognostic factors of patients receiving laryngeal cancer surgery(P<0.05).The results of ROC curve analysis showed that the area under the curve of serum let-7a level in predicting the prognosis of patients receiving laryn-geal cancer surgery was 0.923,the cut-off value was 0.66,the sensitivity was 85.70%,and the specificity was 84.40%.Conclusion Serum let-7a is an independent prognostic factor for patients receiving laryngeal cancer surgery,and is of great significance for predicting the prognosis of relevant patients.