阿司匹林联合阿托伐他汀钙调节脑血栓的疗效及安全性

Efficacy and safety of aspirin combined with atorvastatin calcium in regulating cerebral thrombosis

目的分析阿司匹林联合阿托伐他汀钙调节脑血栓的临床疗效及对其安全性、凝血指标、神经功能的影响。方法80例脑血栓患者,随机分为研究组与对照组,各40例。对照组予以阿司匹林治疗,研究组加用阿托伐他汀钙治疗。比较两组功能恢复情况、血液流变学指标、治疗效果、不良反应发生情况。结果治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分较治疗前均降低,Barthel指数较治疗前均升高,且研究组治疗后NIHSS评分(8.46±1.75)分低于对照组的(11.07±2.43)分,Barthel指数(73.28±8.26)分高于对照组的(64.98±7.35)分,差异有统计学意义(P<0.05)。治疗后,两组血浆粘度、高切全血粘度、低切全血粘度低于治疗前,研究组血浆粘度、高切全血粘度、低切全血粘度分别为(1.42±0.14)、(5.07±0.21)、(7.13±0.25)mPa·s,均低于对照组的(1.57±0.18)、(5.94±0.36)、(8.95±0.31)mPa·s,差异有统计学意义(P<0.05)。研究组治疗总有效率为95.00%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿司匹林与阿托伐他汀钙联合应用,能够显著改善血流状况,改善患者神经功能,提升临床治疗效果,改善患者生活质量。

Objective To analyze the clinical efficacy of aspirin combined with atorvastatin calcium in regulating cerebral thrombosis,and its influence on safety,coagulation indexes and neurological function.Methods A total of 80 patients with cerebral thrombosis were randomly divided into the research group and the control group,with 40 cases in each group.The control group was treated with aspirin,and the research group was additionally treated with atorvastatin calcium.The functional recovery,hemorheological indexes,therapeutic effects,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the National Institutes of Health stroke scale(NIHSS)score in the two groups were lower than that of this group before treatment,and the Barthel index was higher than that of this group before treatment.After treatment,the NIHSS score(8.46±1.75)points of the research group was lower than(11.07±2.43)points of the control group,and the Barthel index(73.28±8.26)points was higher than(64.98±7.35)points of the control group.All the differences were statistically significant(P<0.05).After treatment,the plasma viscosity,high-shear whole blood viscosity and low-shear whole blood viscosity of the two groups were lower than those of this group before treatment,and the plasma viscosity,high-shear whole blood viscosity and low-shear whole blood viscosity of the research group were(1.42±0.14),(5.07±0.21),and(7.13±0.25)mPa·s,which were lower than(1.57±0.18),(5.94±0.36),and(8.95±0.31)mPa·s of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the research group was 95.00%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of aspirin and atorvastatin calcium can significantly improve the blood flow and neurological function,enhance the clinical treatment effect and improve the quality of life of patients.