血清肿瘤标志物联合检验诊断结直肠癌的效果

Effect of combined test of serum tumor markers in the diagnosis of colorectal cancer

目的探讨在结直肠癌诊断中采用血清肿瘤标志物联合检验的临床效果。方法选取30例经病理检测确诊为结直肠癌的患者作为观察组,另选择同期30例健康体检者作为对照组。两组分别在清晨空腹状态下抽取其肘静脉血,检验血清肿瘤标志物。比较两组血清肿瘤标志物水平、单一血清肿瘤标志物检验与联合检验结直肠癌阳性率。结果观察组癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)、糖类抗原72-4(CA72-4)水平分别为(9.62±4.15)μg/L、(42.65±9.86)U/ml、(42.95±11.42)U/ml、(9.12±2.84)U/ml,均高于对照组的(3.18±1.12)μg/L、(13.65±5.96)U/ml、(23.19±9.12)U/ml、(4.03±1.68)U/ml,差异均有统计学意义(P<0.05)。CEA、CA199、CA125、CA72-4单一检验结直肠癌阳性率分别为60.00%(18/30)、66.67%(20/30)、70.00%(21/30)、63.33%(19/30),联合检验结直肠癌阳性率为96.67%(29/30);血清肿瘤标志物联合检验结直肠癌阳性率高于单一检验,差异有统计学意义(P<0.05)。结论结直肠癌患者血清肿瘤标志物指标水平较高,可通过检验血清肿瘤标志物为临床诊断提供参考。同时联合血清肿瘤标志物检验结直肠癌阳性诊断率更高,能进一步提升临床诊断准确率,为疾病治疗提供参考。

Objective To discuss the clinical effect of combined test of serum tumor markers in the diagnosis of colorectal cancer.Methods 30 patients with colorectal cancer diagnosed by pathological examination were selected as the observation group.Another 30 cases of healthy subjects in the same period were selected as the control group.The elbow venous blood of the two groups was collected in the morning under fasting state to test the serum tumor markers.The levels of serum tumor markers,and the positive rates of single serum tumor marker test and combined test for colorectal cancer were compared between the two groups.Results The levels of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125)and carbohydrate antigen 72-4(CA72-4)in the observation group were(9.62±4.15)μg/L,(42.65±9.86)U/ml,(42.95±11.42)U/ml,and(9.12±2.84)U/ml,which were higher than(3.18±1.12)μg/L,(13.65±5.96)U/ml,(23.19±9.12)U/ml,and(4.03±1.68)U/ml in the control group,and the differences were statistically significant(P<0.05).The positive rates of CEA,CA199,CA125,and CA72-4 for colorectal cancer by single test were 60.00%(18/30),66.67%(20/30),70.00%(21/30),and 63.33%(19/30),respectively,and the positive rate of colorectal cancer by combined test was 96.67%(29/30).The positive rate of colorectal cancer by combined test of serum tumor markers was higher than that of by single test,and the difference was statistically significant(P<0.05).Conclusion The level of serum tumor markers in patients with colorectal cancer is high,which can provide reference for clinical diagnosis by testing serum tumor markers.At the same time,combined test of serum tumor markers has higher positive rate for colorectal cancer,which can further improve the accuracy of clinical diagnosis and provide reference for disease treatment.