半夏泻心汤加减治疗2型糖尿病脾虚胃滞证的临床效果及对HbA1c水平的影响分析

Effect of modified Banxia Xiexin Decoction on the treatment of type 2 diabetes mellitus with spleen deficiency and stomach stagnation syndrome and its influence on HbA1c level

目的观察2型糖尿病脾虚胃滞证患者以半夏泻心汤加减进行诊治的临床疗效,并分析患者糖化血红蛋白(HbA1c)水平的改善情况。方法60例2型糖尿病脾虚胃滞证患者,根据接诊先后顺序分为观察组与对照组,各30例。对照组应用盐酸二甲双胍肠溶片治疗,观察组应用半夏泻心汤加减治疗。比较两组葡萄糖耐量、HbA1c、安全性。结果治疗后,两组0、30、60、90、120 min的葡萄糖耐量及HbA1c均低于本组治疗前,且观察组HbA1c(6.03±0.53)%低于对照组的(6.82±0.67)%,差异均有统计学意义(P<0.05)。两组患者均未出现不良反应。结论针对糖尿病脾虚胃滞证患者,实施半夏泻心汤加减治疗,对于患者血糖水平的积极控制有非常良好的促进作用,可以帮助改善患者脾虚胃滞的症侯表现,具有十分确切的临床诊治疗效,值得推广。

Objective To observe the clinical efficacy of modified Banxia Xiexin Decoction on the treatment of type 2 diabetes mellitus with spleen deficiency and stomach stagnation syndrome and its influence on glycosylated hemoglobin(HbA1c)level.Methods A total of 60 cases of type 2 diabetes mellitus with spleen deficiency and stomach stagnation syndrome were divided into observation group and control group according to the order of admission,with 30 cases in each group.The control group was treated with metformin hydrochloride enteric-coated tablets,and the observation group was treated with modified Banxia Xiexin Decoction.The glucose tolerance,HbA1c and safety were compared between the two groups.Results After treatment,the glucose tolerance and HbA1c at 0,30,60,90 and 120 min in both groups were lower than those before treatment in this group,and HbA1c(6.03±0.53)%in the observation group was lower than that of(6.82±0.67)%in the control group,and the differences were statistically significant(P<0.05).No adverse reactions were observed in both groups.Conclusion For the diabetes mellitus with spleen deficiency and stomach stagnation syndrome,the implementation of modified Banxia Xiexin Decoction can promote the positive control of blood glucose level and help improve the symptoms of spleen deficiency and stomach stagnation.It has a very exact clinical diagnosis and treatment effect,and is worth popularizing.