慢性阻塞性肺疾病合并念珠菌病相关危险因素研究进展

Advances in candidiasis in chronic obstructive pulmonary disease

念珠菌属(Candida species)是最常见的条件致病菌之一,其所导致的疾病在侵袭性真菌感染(invasive fungal disease,IFD)中占首位。慢性阻塞性肺疾病患者年龄较大,常合并其他基础疾病,存在营养障碍、免疫受损及念珠菌定植等危险因素,加上临床应用机械通气、广谱抗生素及糖皮质激素等治疗措施,是合并念珠菌病的高危人群。慢性阻塞性肺疾病患者继发念珠菌感染最常见的部位为呼吸道,合并口咽部及消化道感染的患者也有报道。本文针对上述危险因素进行综述,旨在加深临床工作者对该疾病的认识,进一步指导临床诊治。

Candida species,one of the most common opportunistic pathogens,is the leading cause of invasive fungal diseases.Risk factors,such as ageing,comorbidity,dystrophia,immunocompromised,mechanical ventilation,using of broad-spectrum antibiotics or glucocorticoids and candida colonization,contribute to candidiasis in chronic obstructive pulmonary disease(COPD)patients,which is commonly in respiratory tract,also involves oropharyngeal or digestive tract infection.We reviewed and summarized the literatures of risk factors of candidiasis in COPD patients,aimed to deepen the understanding of the disease and further guide clinical diagnosis and treatment.