冬病夏治穴位贴敷治疗支气管哮喘临床疗效及对血清S1P、LXA4表达水平影响

Clinical Effect on the Treatment of Bronchial Asthma by Acupoint Application of Summer Treatment for Winter Disease and Influence on the Expression Levels of Serum S1P and LXA4

目的探讨冬病夏治穴位贴敷治疗支气管哮喘的临床效果以及对血清1-磷酸鞘氨醇(S1P)、脂氧素A4(LXA4)表达水平的影响。方法选取2018年12月—2020年9月本溪市中医院门诊收治的68例支气管哮喘患者作为研究对象,采用随机数字表法随机分为对照组和治疗组,每组各34例。对照组予基础治疗,治疗组在此基础上加用冬病夏治穴位贴敷治疗。比较两组患者治疗前后中医证候疗效、哮喘控制率、肺功能、外周血嗜酸性粒细胞计数(EOS)、血清S1P和LXA4水平变化情况。结果治疗组中医证候疗效(94.12^%)明显高于对照组(73.53%),两组间数据相比较差异具有统计学意义(P<0.05)。治疗结束后两组患者的哮喘控制率、肺功能、血清LXA4表达水平均较治疗前明显提高,两组间数据相比较差异具有统计学意义(P<0.05);且治疗组的提高程度明显优于对照组,两组间数据相比较差异具有统计学意义(P<0.05)。治疗结束后两组患者的外周血EOS水平、血清S1P表达水平均较治疗前明显降低,两组间数据相比较差异具有统计学意义(P<0.05);且治疗组的降低程度明显优于对照组,两组间数据相比较差异具有统计学意义(P<0.05)。结论冬病夏治穴位贴敷治疗支气管哮喘患者临床疗效显著,可有效改善支气管哮喘患者中医证候,提高哮喘控制率、肺功能及血清LXA4表达水平,降低外周血EOS水平及血清S1P表达水平,减轻气道炎症反应,具有临床推广价值。

Objective To observe the clinical effect on the treatment of bronchial asthma by acupoint application of summer treatment for winter disease and influence on the expression levels of serum sphingosine 1-phosphate(S1 P)and lipoxin A4(LXA4). Methods 68 patients with bronchial asthma in the respiratory outpatient department of Benxi hospital of traditional Chinese medicine from December 2018 to September 2020 were selected as the research objects. They were randomly divided into control group and treatment group with 34 cases in each group. The control group was given basic treatment,the treatment group was treated with acupoint application of summer treatment for winter disease on the basis of the control group. The traditional Chinese medicine syndrome efficacy,asthma control rate,lung function,peripheral blood eosinophil count(EOS),serum S1 P and LXA4 levels were compared between the two groups before and after treatment. Results The curative effect of traditional Chinese medicine syndrome in the treatment group(94.12%)was significantly higher than that in the control group(73.53%),and the difference between the two groups was statistically significant(P<0.05). After treatment,the asthma control rate,lung function and serum LXA4 expression level of the two groups were significantly improved compared with those before treatment(P<0.05);and the improvement degree of the treatment group was significantly better than that of the control group,the difference between the two groups was statistically significant(P<0.05). After treatment,peripheral blood EOS count and serum S1 P expression level of the two groups were significantly lower than those before treatment,and the difference between the two groups was statistically significant(P<0.05);and the reduction degree of the treatment group was significantly better than that in the control group,the difference between the two groups was statistically significant(P<0.05). Conclusion The clinical effect of acupoint application of summer treatment for winter disease in the treatment of bronchial asthma is significant,which can effectively improve the traditional Chinese medicine syndrome of bronchial asthma,asthma control rate,lung function and serum LXA4 expression level,reduce the peripheral blood EOS count,serum S1 P expression level and the airway inflammatory reaction,which has clinical promotion value.