高致吐性化疗药不良反应的综合管理工作模式在肺癌治疗中的临床研究

Clinical Research on Comprehensive Management Mode of Adverse Drug Reactions of Highly Emetogenic Chemotherapy Drugs in the Treatment of Lung Cancer

目的:探讨高致吐性化疗药不良反应的综合管理工作模式在肺癌治疗中的临床评价。方法:前瞻性收集2019年6月至2020年9月于该院住院并接受首次化疗的104例肺癌患者作为研究对象,采用抽签法随机分为研究组(n=52)和对照组(n=52)。研究组患者采用综合管理工作模式,对照组患者采用肿瘤科常规工作治疗模式。比较两组患者的恶心严重程度、呕吐频次和患者满意度。结果:104例患者均获得随访,随访时间为11.1~14.2个月,平均(12.4±1.3)个月。两组患者化疗方案基本一致,社会人口学资料所有指标的差异无统计学意义(P>0.05)。采用综合管理工作模式后,研究组患者的恶心严重程度、呕吐频次均低于对照组,差异有统计学意义(P<0.05)。研究组患者的满意度评分为(95.24±5.98)分,高于对照组的(90.32±6.14)分,差异有统计学意义(t=3.124,P<0.01)。结论:综合管理工作模式能够有效促进医护之间的密切配合,在降低患者恶心严重程度、呕吐频次以及提高患者满意度等方面均取得了较好的效果,提高了患者的无呕控制质量,便于患者化疗的顺利进行。

OBJECTIVE:To probe into the clinical evaluation on comprehensive management mode of adverse drug reactions of highly emetogenic chemotherapy drugs in the treatment of lung cancer.METHODS:Totally 104 patients with lung cancer who were hospitalized in this hospital and received the first chemotherapy from Jun.2019 to Sept.2020 were prospectively extracted to be randomly divided into the study group(n=52)and the control group(n=52)by drawing lots.The study group was given comprehensive management mode,while the control group received the routine treatment mode of the oncology department.The severity of nausea,frequency of vomiting,and patient satisfaction were compared between two groups.RESULTS:One hundred and four patients were followed up for 11.1 months to 14.2 months,with an average of(12.4±1.3)months.The chemotherapy regimens of two groups were basically the same,and there was no statistically significant difference in all indicators of sociodemographic data(P>0.05).However,the severity of nausea and frequency of vomiting in the study group were lower than those in the control group after the implementation of comprehensive management mode,the difference was statistically significant(P<0.05).The satisfaction score of the study group was(95.24±5.98)scores,higher than(90.32±6.14)scores of the control group,the difference was statistically significant(t=3.124,P<0.01).CONCLUSIONS:The comprehensive management mode can effectively promote the close cooperation between clinicians and nurses,and has achieved better results in reducing the severity of nausea,frequency of vomiting and improving patient satisfaction,improving the quality of vomit-free control and facilitating the smooth implementation of chemotherapy for patients.