线粒体动力学与衰老相关疾病的研究进展

Research progress on mitochondrial dynamics and age-related diseases

线粒体动力学影响线粒体的形态和功能。随增龄线粒体动力学失衡,导致线粒体功能障碍,加速了老化进展,与衰老相关疾病的发生和发展密切相关,但目前为止,衰老和线粒体动力学之间的具体机制尚不明确。本综述分析了线粒体动力学与衰老的关系,探索了线粒体动力学对衰老相关疾病发生和发展的作用机制,旨在为研发衰老相关疾病的药物提供新的治疗靶点和策略。

Mitochondrial dynamics regulates mitochondrial morphology and functions.Imbalance in mitochondrial dynamics with aging leads to mitochondrial dysfunction,accelerates the aging process and is closely related to the occurrence and progression of age-related diseases.However,the specifics of the relationship between aging and altered mitochondrial dynamics are still not fully understood.Here,we review the link between mitochondrial dynamics and aging,and discuss mechanisms underlying age-related diseases associated with altered mitochondrial dynamics,aiming to identify novel therapeutic targets and strategies for the management of age-related diseases.