中性粒细胞的昼夜节律研究进展

Research progress on circadian rhythm of neutrophils

昼夜节律是机体为适应24 h波动的内外环境变化而演化出的生理调节机制,对包括免疫系统在内的机体众多生理和病理过程发挥重要作用。中性粒细胞作为人体循环中最主要的免疫细胞,其数量和表型也表现出明显的昼夜波动的规律。越来越多的研究显示,中性粒细胞昼夜节律的细胞机制和分子机制与疾病相关。该文结合与中性粒细胞昼夜节律相关的最新研究,从骨髓中中性粒细胞的招募、中性粒细胞的老化及其对机体各组织的浸润等方面对其作简要介绍,并从干预中性粒细胞老化相关趋化因子、时间疗法等角度讨论基于中性粒细胞昼夜节律相关机制的治疗前景。

Circadian rhythm is a physiological regulation mechanism evolved by the body to adapt to the 24-hour fluctuations in the internal and external environment.It plays an important role in many physiological and pathological processes including the immune system.Neutrophils are the most important immune cells in the human circulation,and their numbers and phenotypes also show obvious circadian fluctuations.A growing number of studies have shown that the cellular and molecular mechanisms of neutrophil circadian rhythms are disease-related.Combining the latest research on neutrophil circadian rhythm,this article briefly introduces the recruitment of neutrophils in the bone marrow,the aging of neutrophils and their infiltration into various tissues of the body,and discusses the interventions.It also discusses the therapeutic prospects based on neutrophil circadian rhythm-related mechanisms from the perspectives of intervening neutrophil aging-related chemokines and chronotherapy.