miR-124在卒中后脑缺血损伤与修复中的作用及机制研究进展

Research progress on the role and mechanism of miR-124 in cerebral ischemia injury and repair after stroke

脑卒中是成人因病致死和致残的主要原因之一,缺血性卒中为其主要类型。虽然随着溶栓、机械取栓技术的成熟,卒中的病死率逐年下降,但是大部分幸存者可能会有慢性功能障碍,而临床尚缺乏促进卒中后功能修复的药物。缺血性脑卒中后,miR-124在外周血液和脑组织中表达均发生改变,通过靶向调节基因和调控病理过程广泛参与缺血性卒中后的氧化应激、神经炎症、细胞凋亡、神经分化等。文章就miR-124在卒中后脑缺血损伤与修复中的作用及机制研究进展做一综述。

Stroke is one of the major causes of disease-induced death and disability in adults,and ischemic stroke is the main type.With the maturity of thrombolysis and mechanical thrombectomy,the mortality rate of stroke has decreased year by year,but most of the survivors may develop into patients with chronic dysfunction. Unfortunately,there is a lack of clinical drugs to promote functional repair after stroke. The expression of miR-124 changes in peripheral blood and brain tissue after ischemic stroke. The miR-124 is widely involved in the processes of oxidative stress,neuroinflammation,apoptosis and neural differentiation via targeting regulatory genes and regulating pathological processes. In this paper,it was reviewed the research progress on the role and mechanism of miR-124 in cerebral ischemia injury and repair after stroke.