摘要
Background:The first Coronavirus Disease 2019(COVID-19)outbreak occurred in Wuhan,Hubei Province,China,in December 2019.It originated from a novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 12 November 2021,above 251,788,329 people have been infected and 5,077,907 deaths deaths have been reported globally.The new COVID-19 belongs to the genus Coronavirus with its high mutation rate in the Coronaviridae.The present study aimed to investigate the problems caused by the mutation and its effects on the immune system.Methods:We used Google Scholar,Web of science,Scopus,and PubMed for searching the literature regarding genetic variation in Coronavirus.Results:The publicly available literature in this area was reviewed to summarize the information about the genetic variation of this virus,phylogeny and genome structure,its relationship with the ABO blood group,genome variation,mutations in hotspots,and spike surface glycoprotein.Conclusion:Finally,it was concluded that COVID-19 can mutate;therefore,health authorities are required to remain cautious and completely prepared.
