新型肝动脉栓塞微球制剂的制备

Preparation of novel microsphere for hepatic arterial embolism

开发了一种适合肝动脉灌注化疗栓塞(TACE)用的姜黄素载药微球,并探究其对肝癌的治疗效果.以聚乙烯醇(PVA)为载体,采用乳液交联法制备微球,观察微球的外观和粒度,证明微球对癌细胞的抑制作用,在VX2兔模型中评估肝动脉栓塞微球治疗肝癌的功效.扫描电镜和粒度分析显示制备的微球球形完整;生物安全性证明微球材料安全指数较高;药效学研究表明姜黄素栓塞微球可在栓塞给药后有效发挥动脉栓塞作用,提高肝癌的治疗效果.本研究成功地制备了姜黄素栓塞微球,有望将其用于栓塞以提高TACE在肝癌中的治疗效果.

To develop curcumin loaded microspheres suitable for transcatheter arterial chemoembolization(TACE)and to explore its therapeutic effect on liver cancer,microspheres were prepared with polyvinyl alcohol(PVA)as a carrier material by emulsification cross-linking method.The morphology and particle size distribution of the drug-loaded microspheres were evaluated.The inhibitory effects of microspheres on cancer cells were observed.We used VX2 liver cancer rabbit models to discuss the effectiveness of curcumin-loaded microspheres for hepatic artery embolization.Scanning electron microscope and particle size analysis showed that the microspheres had good sphericity.Safety testing determined that the safety index of microspheres was higher.The pharmacodynamic study showed that curcumin embolic microspheres could effectively play the role of arterial embolization after embolization administration and improve the therapeutic effect of liver cancer.Curcumin embolic microspheres had been successfully prepared in this study,which were expected to be used for embolization to improve the therapeutic efficiency of TACE in liver cancer.