绝经综合征焦虑抑郁情绪神经内分泌机制研究进展

Research Progress on Neuroendocrine of Anxiety and Depression in Menopausal Syndrome

该文通过浏览近10年文献,对目前国内外学者研究关于绝经综合征时期妇女产生焦虑抑郁状态相关的文献资料进行分析,探讨神经递质与内分泌系统对女性绝经综合征焦虑抑郁情绪的影响。表明机体分泌的5-羟色胺(5-hydroxtryptamine,5-HT)、β-内啡肽(β-endorphin,β-EP)及雌二醇(estradiol,E2)水平与绝经综合征时期焦虑抑郁等情绪的产生有密切关系。针对患者提供个体化治疗方案,可以调节5-HT、β-EP及E2水平,患者临床上焦虑抑郁状态能够得到有效地改善,生活质量有所提高。该文为治疗绝经综合征时期情绪障碍提供了相应的研究资料。

By browsing the literature in recent 10 years,this paper analyzes the literature related to anxiety and depression in women with menopausal syndrome,to explore the effects of neurotransmitters and endocrine system on anxiety and depression of female menopausal syndrome. 5-hydroxytryptamine(5-HT)secreted by the body β-endorphins(β-endorphin,β-EP)and estradiol(E2)levels are closely related to anxiety and depression in menopausal syndrome. Individualized treatment is provided for patients to regulate 5-HT,β-EP and E2,can effectively improve the clinical state of anxiety and depression and improve the quality of life,which provides corresponding research value for the treatment of emotional disorders in menopausal syndrome.