摘要
Background:In Nigeria,malaria is a leading cause of hospital admission and death.The country accounts for highest malaria cases and deaths globally.About 25% of all malaria cases and deaths in the world occurs in Nigeria.In 2010,malaria was reported to account for 60% of all outpatient visits and responsible for 30% of all hospital admission of children under the age of five years leaving in Nigeria.Objective:The goal of this research work was to investigate the possible role of the state of protein nutrition,kidney and liver functions of the under 5 years children with P.falciparum malaria;the assessment of these biochemical parameters as possible indicator of P.falciparum infection in the studied subjects and the effect of home-based oral chloroquine treatment in these children leaving in Jos metropolis.Method:Total of 93 children within the age range of 1 to 59 months and leaving in Jos North,Central Nigeria were recruited for this cross-sectional study.Malaria parasite identification was done using microscopic examination of Leishman-stained thick and thin blood films while the complete blood count was carried out using Beckman Coulter Analyzer.Results:The serum albumin concentration of(37.63±0.82 g/L)obtained in the malaria-free children was higher than concentration of(34.07±1.90 g/L)obtained in the chloroquine treated children with malaria,but not different from those obtained in the untreated uncomplicated malaria(37.35±1.19 g/L)and untreated severe malaria(37.43±1.02 g/L)groups.The Serum globulin concentration of 35.09±1.95 g/L,obtained in the untreated simple malaria group was higher than 30.18±1.30 g/L in the control group,34.57±2.59 g/L in the untreated severe malaria group and chloroquine treated malaria with 30.71±2.38 g/L,respectively.Conclusion:This study suggests that the biochemical parameters of serum creatinine,serum albumin,total protein,and globulin,serum alkaline phosphatase,serum alanine aminotransferase and serum aspartate aminotransferase are not sensitive indicators of P.falciparum infection in studied children with malaria.It also demonstrated that involvement of liver and kidney or impairment of their functions could be ruled out in the pathogenesis of malaria in this group of children.These results further shows that there was no significant effect of first-line treatment with oral chloroquine on the studied biochemical parameters in the study population.
