心力衰竭伴快速心房颤动患者采用胺碘酮急诊抢救治疗及对24 h心室率影响分析

Emergency treatment with amiodarone in patients with heart failure complicated with rapid atrial fibrillation and its effect on 24-hour ventricular rate

目的分析心力衰竭伴快速心房颤动(简称:心衰伴快速房颤)患者接受胺碘酮急诊抢救治疗的效果及对24 h心室率的影响。方法将2017年1月—2020年12月急诊接诊且行西地兰治疗的60例心衰伴快速房颤患者作为对照组,将同期急诊接诊且行胺碘酮治疗的60例心衰伴快速房颤患者作为观察组,对组间心功能指标、炎症因子水平、心室率、临床疗效、药物不良反应展开分析。结果①组间心功能指标、炎症因子水平在治疗前无差异,P>0.05;观察组心功能指标、炎症因子水平在治疗后优于对照组,P<0.05;②组间心室率在治疗前无差异,P>0.05;观察组治疗后4 h、12 h、24 h心室率均低于对照组,P<0.05;③观察组5例无效(8.33%),对照组14例无效(23.33%),P<0.05;④观察组药物不良反应率(3.33%)与对照组药物不良反应率(5.00%)无差异,P>0.05。结论在急诊抢救心衰伴快速房颤患者时采用胺碘酮,可以改善患者心功能、炎症反应、心室率,加之无明显不良反应,值得推广。

Objective To analyze the efficacy of emergency treatment with amiodarone and its influence on 24-hour ventricular rate in patients with heart failure and rapid atrial fibrillation.Methods From January 2017 to December 2020,60 patients with heart failure and rapid atrial fibrillation who received emergency treatment and cedilanide treatment were selected as the control group,and 60 patients with heart failure and rapid atrial fibrillation who received emergency treatment and amiodarone treatment at the same period were selected as the observation group.Results①There was no significant difference in cardiac function index and inflammatory factors level between the two groups before treatment,P>0.05.The cardiac function index and inflammatory factors level of the observation group were more improved than those of the control group after treatment,P<0.05.②There was no significant difference in ventricular rate between the two groups before treatment,P>0.05.The ventricular rates of the observation group at 4 h,12 h and 24 h after treatment were lower than those of the control group,P<0.05.③Treatment for 5 cases(8.33%)in the observation group,14 cases(23.33%)in the control group were ineffective,P<0.05.④There was no significant difference in the adverse drug reaction incidence between the observation group(3.33%)and the control group(5.00%),P>0.05.Conclusion Amiodarone could improve the cardiac function,inflammatory reaction and ventricular rate of patients with heart failure and rapid atrial fibrillation in emergency treatment,and there was no obvious adverse reaction,so it is worthy of promotion.