多囊卵巢综合征患者性激素水平与胰岛素抵抗关系

Relationship between sex hormone levels and insulin resistance in patients with polycystic ovary syndrome

目的分析多囊卵巢综合征患者性激素水平与胰岛素抵抗关系。方法此次研究所设置的观察组对象为我院收入的多囊卵巢综合征患者,均在2017年5月—2020年7月入院,入选患者共100例。选取同一时期到我院进行相关检查的健康育龄女性100例作为对照组。分别检测、统计2组女性的性激素[包括性激素黄体生成素(LH)、睾酮(T)、雌二醇(E2)、卵泡刺激素(FSH)]、空腹血糖(FBG)、空腹胰岛素(FINS)以及胰岛素抵抗指数,对性激素水平与胰岛素抵抗关系进行分析。结果相比于对照组,观察组女性的LH、T水平更高(P<0.05),E2、FSH水平更低(P<0.05),且FBG、FINS、胰岛素抵抗指数均更高(P<0.05)。观察组中,胰岛素抵抗与非胰岛素抵抗患者的性激素水平与胰岛素抵抗指数,胰岛素抵抗女性与非胰岛素抵抗女性的LH、TE2、FSH水平均具有差异(P<0.05)。LH、E2、FSH水平与胰岛素抵抗指数无相关性(P>0.05),T水平与胰岛素抵抗指数呈正相关(P<0.05)。结论多囊卵巢综合征患者的性激素出现了一定的分泌紊乱现象,其中T水平与胰岛素抵抗具有相关性。

Objective To analyze the relationship between sex hormone levels and insulin resistance in patients with polycystic ovary syndrome.Methods The subjects of the observation group set up in this study were patients with polycystic ovary syndrome admitted to our hospital,all of whom were admitted from May 2017 to July 2020,and a total of 100 patients were enrolled.One hundred healthy women of childbearing age who came to our hospital for relevant examinations during the same period were selected as the control group.Sex hormone[including luteinizing hormone(LH),testosteron(T),estradiol(E2),follicle stimulating hormone(FSH)]levels,fasting blood glucose(FBG)level,fasting insulin(FINS)level,and insulin resistance index were detected and summerized in the two groups of women separately,and the relationship between sex hormone levels and insulin resistance was analyzed.Results Compared with the control group,women in the observation group had higher LH and T levels(P<0.05),lower E2 and FSH levels(P<0.05),and higher FBG,FINS levels,and insulin resistance index(P<0.05).In the observation group,sex hormone levels and insulin resistance index in insulin-resistant and non-insulin-resistant patients,and LH,TE2,and FSH levels in insulin-resistant and non-insulin-resistant women were different(P<0.05).There was no correlation between LH,E2,and FSH levels and insulin resistance index(P>0.05),and T level were positively correlated with insulin resistance index(P<0.05).Conclusion Patients with polycystic ovary syndrome showed some disturbance in the secretion of sex hormones,among which T level were correlated with insulin resistance.