补阳还五汤加减治疗肾病综合征的疗效及临床价值

The curative effect and clinical value of the nephrotic syndrome treatment with the addition or reduction of Buyang Huanwu decoction

目的分析补阳还五汤加减治疗肾病综合征(NS)的临床疗效。方法选择本院2019年1月—2021年1月住院治疗的120例NS患者,通过随机数字表法分组,参照组60例患者采纳常规西医治疗,试验组60例患者在参照组基础上予以补阳还五汤治疗,对比2组临床疗效、中医症候积分、肾功能指标、不良反应总发生率。结果试验组临床总有效率(96.67%)高于参照组(80.00%),试验组治疗后浮肿少尿、腰膝酸软、腹部胀满、头晕乏力积分均低于参照组,差异均有统计学意义(P<0.05)。治疗后试验组24 h尿蛋白、尿素氮均比参照组低,差异有统计学意义P<0.05,血肌酐治疗前后差异无统计学意义P>0.05。试验组不良反应总发生率(5.00%)与参照组(6.67%)比较,差异无统计学意义(P>0.05)。结论补阳还五汤可有效改善NS患者临床症状、肾功能,降低蛋白尿,且不良反应较少,安全性较高,疗效确切。

Objective To analyze the clinical effect of addition or reduction of Buyang Huanwu decoction in the treatment of nephrotic syndrome(NS).Methods A total of 120 NS patients in our hospital from January 2019 to January 2021 were divided into two groups by random digital table method.Sixty patients in the control group were treated by conventional western medicine,60 patients in the experimental group were treated with Buyang Huanwu decoction on the basis of control group.The clinical efficacy,traditional Chinese medicine syndrome score,renal function index and total incidence of adverse reactions were compared.Results The total clinical effective rate of the experimental group(96.67%)was higher than that of the control group(80.00%).The scores of edema and oliguria,lumbar and knee pain and limpness,abdominal distention and dizziness after treatment in the experimental group were all lower than those in the control group,with statistical significance(P<0.05).After treatment,24 h urinary protein volume and blood urea nitrogen level in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05),while there was no statistically significant difference in serum creatinine before and after treatment(P>0.05).There was no significant difference in the total incidence of adverse reactions between the experimental group(5.00%)and the control group(6.67%,P>0.05).Conclusion Buyang Huanwu decoction could effectively improve the clinical symptoms and renal function,reduce proteinuria,and had less adverse reactions,high safety level and accurate curative effect.