雾化吸入干扰素-α治疗儿童疱疹性咽峡炎临床疗效评价

Evaluation on the clinical efficacy of interferon-αnebulized inhalation in the treatment of herpetic angina in children

目的探讨雾化吸入干扰素-α治疗对儿童疱疹性咽峡炎的治疗效果的影响。方法本研究纳入2019年1月—2021年1月在清远市妇幼保健院住院治疗的126例疱疹性咽峡炎儿童。所有参与该研究的患儿被随机平均分为2组:对照组(63人)和干预组(63人)。对照组进行常规治疗方案,干预组在对照组基础上雾化吸入干扰素-α治疗。比较2组治疗效果的差异性。结果干预组患儿平均发热天数(1.86±0.97天)较对照组(2.44±0.89天)低;干预组心肌酶升高比例较对照组低,组间差异有统计学意义(P<0.01)。干预组中显效(50.8%)占主要比例,而对照组中有效(74.6%)占主要比例,并且干预组总有效率(98.4%)高于对照组(96.8%)(P<0.05)。干预组住院天数(5.02±1.85天)较对照组(5.68±1.68天)降低,组间差异有统计学意义(P<0.05)。结论在常规治疗的基础上加用雾化吸入干扰素-α治疗对提高儿童疱疹性咽峡炎的疗效有促进作用,值得临床推广。

Objective To investigate the effect of nebulized inhalation of interferon-α on the therapeutic effect of herpes angina in children.Methods This study included 126 children with herpetic angina who were hospitalized in Maternal and Child Health Hospital of Qingyuan City from January 2019 to January 2021.All children participating in the study were randomly divided into 2 groups:control group(63 children)and intervention group(63 children).The control group received conventional treatment,and the intervention group was treated with aerosol inhalation of interferon-αon the basis of the control group.The difference of the treatment effect between the two groups were compared.Results The average number of fever days of children in the intervention group(1.86±0.97 days)was lower than that of the control group(2.44±0.89 days);the increase of myocardial enzymes in the intervention group was lower than that of the control group,and the difference was statistically significant(P<0.01).The“obviously effective”(50.8%)in the intervention group accounted for the main proportion,while the“effective”(74.6%)in the control group accounted for the main proportion,and the total effective rate of the intervention group(98.4%)was higher than that of the control group(96.8%,P<0.05).The length of hospitalization in the intervention group(5.02±1.85 days)was smaller than that of the control group(5.68±1.68 days),and the difference was statistically significant(P<0.05).Conclusion The addition of nebulized interferon-α on the basis of conventional treatment could improve the curative effect of herpetic angina in children,and it is worthy of clinical promotion.