摘要
Since December 2019,severe acute respiratory syndrome coronavirus 2 has been found to be the culprit in the coronavirus disease 2019(COVID-19),causing a global pandemic.Despite the existence of many vaccine programs,the number of confirmed cases and fatalities due to COVID-19 is still increasing.Furthermore,a number of variants have been reported.Because of the absence of approved anticoronavirus drugs,the treatment and management of COVID-19 has become a global challenge.Under these circumstances,drug repurposing is an effective method to identify candidate drugs with a shorter cycle of clinical trials.Here,we summarize the current status of the application of drug repurposing in COVID-19,including drug repurposing based on virtual computer screening,network pharmacology,and bioactivity,which may be a beneficial COVID-19 treatment.
基金
supported by the Ph D Start-up Fund of Guangdong Medical University(Grant No.:B2019016)
Administration of Traditional Chinese Medicine of Guangdong Province(Grant No.:20201180)
Science and Technology Special Project of Zhanjiang(Project No.:2019A01009)
Natural Science Foundation of Guangdong Province(Grant No.:2016B030309002)
Basic and Applied Basic Research Program of Guangdong Province(Grant No.:2019A1515110201)
Educational Commission of Guangdong Province(Grant No.:4SG20138G)
Fund of Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang)(Grant No.:ZJW-2019-007)。
