集体细胞迁移的研究模型和分子机制研究

Study on Research Models and Molecular Mechanisms of Collective Cell Migration

集体细胞迁移在大多数生物体的发育过程中起着关键作用。要实现高效且协调的迁移行为,细胞需要整体的细胞骨架调控来产生整体极化的牵引力。研究表明,胞外引导信号的浓度梯度或细胞与胞外基质的相互作用参与诱导极性的产生和起始迁移。集体迁移的细胞间存在相互作用,且这种细胞间的交流对于协调迁移至关重要。基于此,综述不同模式生物发育过程中的集体细胞迁移研究模型和分子机制,以期为相关研究提供借鉴。

Collective cell migration plays a key role during the development of most organisms.To display a coordinated migratory behavior and move more efficiently than cells migrated separately,collectively migrating cells need polarized force and cytoskeletal organization.Studies indicate that external signals,including gradients of signaling molecules and interactions with extra cellular matrix(ECM),induce F-actin polarity and start the migration.Cellular interplay occurs during collective cell migration,and such intercellular communication is essential to coordinated migration.Based on this,the research models and molecular mechanisms of collective cell migration in the development of different model organisms are reviewed in order to provide reference for related research.