A型塞内卡病毒研究进展

Progress on Seneca Virus A

A型塞内卡病毒(Senecavirus A,SVA)是近年来新发的一种能够引起猪水疱性相关疾病的病毒,为小RNA病毒科塞内卡病毒属唯一成员。据报道,该病先后在加拿大、美国、巴西、泰国等国家流行,2015年SVA首次在我国广东省检出,随后多个省、自治区和直辖市均检测到SVA阳性病例,可见SVA已经在我国流行。猪感染SVA后能够引起猪鼻镜及蹄冠处出现水疱、溃烂,严重者甚至出现死亡,其临床症状与口蹄疫、猪水疱病非常相似,难以进行辨别。该病目前尚无商品化疫苗,但已有灭活疫苗、减毒活疫苗以及病毒样颗粒疫苗研究的报道。论文对塞内卡病的病原学、流行病学、致病机理、诊断以及疫苗研究等方面进行概述,为深入研究和防控该病提供理论依据。

Senecavirus A(SVA)is a new virus that can cause vesicular-related diseases in swine in recent years.It is the only member of the Senecavirus genus of the Picornavirus family.According to reports,the disease has been prevalent in Canada,the United States,Brazil,Thailand and other countries.In 2015,SVA was first detected in Guangdong province of our country.Subsequently,positive cases of SVA have been detected in many provinces,autonomous regions and municipalities,which shows that SVA has been prevalent in our country.Pigs infected with SVA can cause blisters and ulcers in the nose and hoof crowns,and even death in severe cases.The clinical symptoms are very similar to FMD and SVD,and it is difficult to distinguish.There is currently no commercial vaccine for this disease,but there have been reports of inactivated vaccines,live attenuated vaccines,and virus-like particle vaccines.This article summarized the etiology,epidemiology,pathogenesis,diagnosis and vaccine research of Seneca disease,and provided theoretical basis for in-depth research and prevention and control of the disease.