表皮生长因子受体基因突变与非小细胞肺癌临床病理特征的相关性研究

Study on the Correlation between Epidermal Growth Factor Receptor Gene Mutation and Clinicopathological Features of Non-Small Cell Lung Cancer

目的 探讨表皮生长因子受体(EGFR)基因突变与非小细胞肺癌(NSCLC)临床病理特征的相关性。方法 选取2016年1月至2019年12月我院收治的171例NSCLC患者,分析NSCLC患者EGFR基因突变情况及EGFR基因突变与临床病理特征的关系。结果 171例NSCLC患者EGFR基因突变率为40.94%,其中敏感突变占比38.01%,耐药突变占比2.92%;EGFR突变型患者与EGFR野生型患者的性别、吸烟史、病理类型比较有统计学差异(P <0.05)。Logistic多因素分析显示,女性、腺癌、无吸烟史是NSCLC患者EGFR基因突变的危险因素(P <0.05)。结论 NSCLC患者中存在一定EGFR基因突变率,EGFR基因突变在女性、腺癌、无吸烟史的NSCLC患者中发生率更高,分析临床病理特征有助于预测NSCLC患者EGFR基因突变情况,为临床治疗提供依据。

Objective To explore the correlation between epidermal growth factor receptor(EGFR)gene mutation and clinicopathological features of non-small cell lung cancer(NSCLC).Methods 171 NSCLC patients admitted to our hospital from January 2016 to December 2019 were selected.The EGFR gene mutation in NSCLC patients,and the correlation between EGFR gene mutation and clinicopathological features were analyzed.Results The EGFR gene mutation rate of 171 NSCLC patients was 40.94%,of which sensitive mutation rate accounting for 38.01%and drug resistance mutation accounting for 2.92%.Statistical difference was found in the gender,smoking history and pathological type between EGFR mutant type patients and EGFR wild type patients(P<0.05).Logistic multivariate analysis showed that female,adenocarcinoma,and no smoking history were the risk factors for EGFR gene mutation in NSCLC patients(P<0.05).Conclusions There is certain EGFR gene mutation rate of NSCLC patients.The EGFR gene mutation rate is higher in female,adenocarcinoma,and no smoking history NSCLC patients.Analysis of clinicopathological features is helpful to predict the EGFR gene mutation of NSCLC patients and provide basis for clinical treatment.