长链非编码RNA在消化道恶性肿瘤上皮-间质转化中的研究进展

Research progress of long non-coding RNA in epithelial-mesenchymal transition in the malignant tumor of digestive tract

上皮-间质转化(epithelial-mesenchymal transition,EMT)是通过一系列复杂的程序转变为具有间质细胞特性的上皮细胞的生物学过程,也是促进肿瘤细胞侵袭和转移的关键因素,EMT在消化道恶性肿瘤的发生发展中起十分重要的作用。长链非编码RNA(long non-coding RNA,lncRNA)可在多个层面调控基因的表达水平,且以特异性表达作用EMT过程,进而影响消化道恶性肿瘤细胞的侵袭和转移。因此,本文主要就近年来EMT相关lncRNA在消化道恶性肿瘤中的调控机制作一概述,从而深入了解消化道恶性肿瘤的发病机制。

Epithelial-mesenchymal transition(EMT)is a biological process that transforms into epithelial cells with stromal cell characteristics through a series of complex procedures.It is also a key factor that promotes the invasion and metastasis of tumor cells.The occurrence and development of malignant tumor of digestive tract are closely related to EMT.Long non-coding RNA(lncRNA)can regulate gene expression levels at multiple levels and specifically affect the EMT process,thus affecting the invasion and metastasis of digestive tract malignancies cells.Therefore,the regulation mechanism of EMT-related lncRNA in malignant tumor of digestive tract in recent years was reviewed in this paper,so as to further understand the pathogenesis of digestive tract malignancies.