丹芪祛瘀止痛汤对慢性萎缩性胃炎患者血清胃蛋白酶原及相关指标的影响

Effect of Danqi Quyu Zhitong decoction on serum PGⅠ,PGⅡand serum related indexes in patients with chronic atrophic gastritis

目的:探讨丹芪祛瘀止痛汤对慢性萎缩性胃炎患者血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及血清相关指标的影响。方法:以90例慢性萎缩性胃炎患者为研究对象,按随机数字表法分为对照组(45例,给予四联杀菌方治疗)和研究组(45例,在对照组治疗的基础上给予丹芪祛瘀止痛汤治疗)。观察两组治疗后临床疗效及不良反应,对比治疗前后中医证候积分、胃黏膜血流量、PGⅠ、PGⅡ、胃泌素17(G-17)、肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)、表皮生长因子(EGF)水平。结果:治疗前,两组胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量、PGⅠ、PGⅡ、G-17、TNF-α、IL-1β、EGF水平比较,差异均无统计学意义(P>0.05);治疗后,两组胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、PGⅠ、G-17、TNF-α、IL-1β水平均较治疗前降低,胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量较治疗前更快,PGⅡ、EGF水平较治疗前升高,与对照组相比,研究组临床疗效、胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、PGⅠ、G-17、TNF-α、IL-1β水平更低,胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量更快,PGⅡ、EGF水平更高,差异均有统计学意义(P<0.05)。在治疗过程中,两组均未出现不良反应。结论:丹芪祛瘀止痛汤能够有效改善慢性萎缩性胃炎患者临床症状,且能够调节胃黏膜血流量、血清PGⅠ、PGⅡ及血清相关指标水平,可在临床应用。

Objecive:To investigate the effect of Danqi Quyu Zhitong decoction on serum PGⅠ,PGⅡand serum related indexes in patients with chronic atrophic gastritis Methods:Taking 90 patients with chronic atrophic gastritis as the research objects,they were divided into control group(45 cases treated with Silian Sterilization decoction)and study group according to the random number table method(45 cases were treated with Danqi Quyu Zhitong decoction on the basis of the treatment of the control group).Observed the clinical efficacy and adverse reactions of the two groups after treatment,and compared the TCM syndrome scores,gastric mucosal blood flow,pepsinogen I(PGⅠ),pepsinogenⅡ(PGⅡ),and gastrin 17(G-17)before and after treatment.Tumor necrosis factor-α(TNF-α),interleukin 1β(IL-1β),epidermal growth factor(EGF)levels.Results:Before treatment,the two groups of gastric cavity had dull pain and pain at fixed locations,obvious pain at night,belching and vomiting acid,dry mouth,bitterness,fatigue,lack of food,loose stools,small curvature of gastric antrum,anterior wall of gastric antrum,large gastric antrum,there was no significant difference in blood flow,PGⅠ,PGⅡ,G-17,TNF-α,IL-1β,and EGF levels in the posterior wall of the gastric antrum(P>0.05).After treatment,the two groups had dull gastric pain and pain was fixed and refused to press,pain at night was obvious,belching and vomiting acid,dry mouth,bitterness,fatigue,lack of food,loose stools,PGⅠ,G-17,TNF-α,IL-1βlevels were lower than before treatment,gastric antrum the blood flow of the minor curvature,the anterior wall of the gastric antrum,the greater curvature of the gastric antrum,and the posterior wall of the gastric antrum were faster than before treatment,and the levels of PGⅡand EGF were higher than those before treatment.Compared with the control group,the study group had clinical efficacy and dull gastric pain in addition,the pain was fixed and refused to press,the pain was obvious at night,belching and vomiting acid,dry mouth and bitterness,fatigue,lack of food,loose stools,lower levels of PGⅠ,G-17,TNF-α,IL-1β,and small curvature of the gastric antrum the blood flow in the anterior wall of the gastric antrum,the greater curvature of the gastric antrum,and the posterior wall of the gastric antrum was faster,and the levels of PGⅡand EGF were higher.The difference was statistically significant(P<0.05).During the treatment,no adverse reactions occurred in the two groups.Conclusion:Danqi Quyu Zhitong decoction can effectively improve the clinical symptoms of patients with chronic atrophic gastritis,and can regulate the gastric mucosal blood flow,serum PGⅠ,PGⅡand serum related index levels,and can be popularized and applied in clinical practice.