胸腺肿瘤免疫治疗的研究进展

Advances in immunotherapy of thymic tumors

胸腺上皮性肿瘤是一种罕见的前纵隔肿瘤,发病率较低,目前手术仍是胸腺肿瘤最主要的治疗手段。然而对于晚期不可切除的胸腺肿瘤来说,非手术治疗是必然选择。传统的治疗方式包括化疗及放疗,但疗效有限。随着免疫治疗应用于临床,部分研究已开展关于胸腺肿瘤免疫治疗的探索。胸腺肿瘤发病率较低,目前的免疫治疗研究多为小型回顾性分析。本文对胸腺肿瘤免疫治疗的临床应用及基础研究进展进行综述。

Thymic epithelial tumor is a rare anterior mediastinal tumor.Surgery is the most important treatment for thymic tumors.However,non-surgical treatment is still an inevitable choice for unresectable advanced thymic tumors.The traditional treatment methods include chemotherapy and radiotherapy,but the effect is limited.With the development of immunotherapy therapy,some studies have attempted the exploration of immunotherapy for thymic tumors.Because of the low incidence rate of thymic tumors,these studies are mostly small retrospective analyses.This article review the clinical and basic research progress of immunotherapy for thymic tumors.