摘要
Chemotherapy is still a kind of important strategy for cancer treatment,but lacking effective delivery system limits the therapeutic outcome.Owing to the excellent biocompatibility,albumin has been employed as drug vehicle;however,it has to face complicated synthesis procedures and still needs an effective technology for the drug delivery evaluation.In this study,a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs;furthermore,the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance imaging.This nanosystem with a stable structure exhibited about 80 nanometer size and 7.7[Mn]mM-1S-1 T1 relaxivity;moreover,the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer therapy.Moreover,the nanocomposites effectively entered into the cancer cells and showed superior antitumor ability;and these treated cells exhibited significant T1 signal.These results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.
基金
supported by the Key Project of Sichuan Education Department(16ZA0399)
the Sichuan Science and Technology Program(2017JY0107)
the Leshan Science and Technology Bureau of China(17GZD041)
Science and Technology Project of Yantian District in Shenzhen City,Guangdong Province,China(20190106)
the Training Programs of Innovation and Entrepreneurship for Undergraduates of Sun Yat-Sen University(20201062).