糖尿病合并白内障患者房水葡萄糖与血糖、糖化血红蛋白间相关性分析

Correlation analysis of aqueous humor glucose and HbA1cin patients with diabetes complicated with cataract

目的评估糖尿病合并白内障患者手术时房水葡萄糖(AHG)水平与血糖(BG)、糖化血红蛋白(HbA1c)之间的关系,了解血糖控制对房水葡萄糖的影响。方法选择接受白内障手术的糖尿病患者30名(平均年龄69.4±9.9岁)。在手术前测量血糖水平;获取3个月内的HbA1c;手术开始时,抽取房水约0.05mL并检测AHG。主要观察AHG与BG相关性以及AHG与HbA1c之间的关系。结果AHG与BG之间存在显着正相关,R=0.70(P<0.01);HbA1c与AHG之间的强正相关,R=0.53(P<0.01);HbA1c与AHG/BG正相关,R=0.82(P<0.01)。结论房水葡萄糖水平和血糖水平之间存在强相关性。不良的血糖控制与房水葡萄糖值增加密切相关。

Objetive To evaluate the relationship between the level of aqueous humor glucose(AHG)and glycosylated hemoglobin(HbA1c)in diabetic patients undergoing cataract surgery,and to understand the effect of glucose control on aqueous humor glucose.Methods Diabetic patients underwent cataract surgery.Blood glucose levels were measured before surgery to obtain HbA1c within 3 months.At the beginning of the operation,0.05 mL aqueous humor was extracted.The main indexes were blood glucose(BG),AHG and HbA1c.The correlation between AHG and BG and the relationship between AHG and HbA1c were mainly observed.Results Thirty patients(mean age 69.4±9.7 years)were enrolled.There was a significant positive correlation between AHG and BG,R=0.70(P<0.01).There was a positive correlation between HbA1c and AHG,R=0.53(P<0.01.)HbA1c was positively correlated with AHG/BG,R=0.82(P<0.01).Conclusion There is a strong correlation between aqueous humor glucose level and blood glucose level.Poor glycemic control is closely associated with increased aqueous humor glucose,reflecting increased glucose permeability in the anterior chamber.