PI3K/AKT信号通路调控骨关节疾病软骨细胞自噬及损伤的机制

Progress in research on PI3K/AKT signaling pathway in autophagy and injury of chondrocytes in osteoarticular diseases

对近年来大骨节病(Kashin-Beck disease,KBD)和骨关节炎(osteoarthritis,OA)中软骨细胞自噬与损伤的研究现状进行综述。PI3K/AKT信号通路和mTOR调控软骨细胞的自噬活性;PI3K/AKT信号通路具有促进软骨细胞增殖的作用,并可通过抑制软骨细胞自噬活性引起细胞损伤。这可能在KBD和OA的发生和进展中具有重要作用,将为揭示骨关节疾病的发病机制和治疗方案提供科学依据。

This paper reviews the status quo of recent years’research on autophagy and damage of chondrocytes in Kashin-Beck disease(KBD)and osteoarthritis(OA).PI3 K/AKT signaling pathway and mTOR regulate the autophagy activity of chondrocytes.PI3 K/AKT signaling pathway can promote the proliferation of chondrocytes and cause their damage by inhibiting their autophagy activity.This might play an important role in the occurrence and progression of bone and joint diseases such as KBD and OA,and provide scientific basis for revealing the pathogenesis and treatment plan of them.