补气活血药重塑肿瘤缺氧微环境的研究思路

Research ideas on remodeling tumor hypoxia microenvironment with drugs of invigorating qi and activating blood circulation

缺氧存在于肿瘤发生、发展全过程,且加速肿瘤细胞侵袭、转移;而改善肿瘤缺氧状况能有效提高药物敏感性,延长肿瘤患者生存期。缺氧诱导因子(HIF)-1α是缺氧主要表达的基因,且与缺氧环境下肿瘤糖代谢异变及血管结构异常密切相关。笔者结合课题组前期研究结果及肿瘤的病理特征,认为肿瘤缺氧的基本病机是气虚血瘀、本虚标实,提出补气活血药(黄芪、莪术配伍)可改善肿瘤缺氧,进而抑制肿瘤生长和转移的构想,为进一步揭示补气活血药抗肿瘤作用机制提供研究思路。

It was found that hypoxia could occur throughout the whole process of tumor development and accelerate the invasion and transfer of tumor cells. It was beneficial to improve tumor hypoxia for effectively increasing drug sensitivity and prolonging the lifetime of tumor patients. Hypoxia inducible factor(HIF)-1α is the main gene expressed in hypoxia, and is closely related to the abnormal glucose metabolism and vascular structure in tumor under the anaerobic environment. Based on the previous research results and the pathological characteristics of the tumor, we believed that the basic pathogenesis of tumor hypoxia is qi deficiency and blood stasis, and origin deficiency and superficiality excess. The idea was put forward those medications used to invigorate qi and activate blood, like Radix Astragali seu Hedysari and Rhizoma Curcumae, could be applied to improve tumor hypoxia and inhibit tumor growth and transfer, which can throw new light on further revealing the anti-tumor mechanism of medications used to invigorate qi and activate blood.