基于对应分析探讨血脂异常患者中医证候与合并病的相关性

Research on the correlation between traditional Chinese medicine syndromes and comorbidities in patients with dyslipidemia by correspondence analysis

目的:探究血脂异常患者中医证候与合并病的相关性,为临床辨证论治提供可参考的理论基础。方法:采用多中心收集的1 019例血脂异常患者的数据资料,建立数据库,并应用SAS 9.4软件进行多元对应分析。结果:在血脂异常的合并病中,冠心病与脾虚气弱证的关系最为紧密(相关距离为0.03925),高血压病与痰瘀互阻证的关系最为紧密(相关距离为0.04790),2型糖尿病与气虚血瘀证的关系最为紧密(相关距离为0.04987),脑梗死与痰浊阻滞证关系最为紧密(相关距离为0.01048)。结论:通过多对多的对应分析方法,可深入挖掘中医复杂的证候体系,提示血脂异常合并冠心病可辅以补脾益气之品,合并高血压病重视活血化痰,合并2型糖尿病联合补气祛瘀方药,合并脑梗死以化痰为主,以期收获较好疗效。

Objective: To explore the correlation between traditional Chinese medicine(TCM) syndromes and comorbidities in patients with dyslipidemia, and provide a theoretical basis for clinical diagnosis and treatment. Methods: Using the data of 1 019 patients with dyslipidemia collected by multiple centers establish a database and the SAS 9.4 software was used for multiple correspondence analysis. Results: Among the combined diseases of dyslipidemia, coronary heart disease was closely related to syndrome of spleen deficiency and weak qi(correlation distance was 0.03925). Hypertension was closely related to syndrome of phlegm and blood stasis(correlation distance was 0.04790). Type 2 diabetes was closely related to syndrome of qi deficiency and blood stasis syndrome(correlation distance was 0.04987). Cerebral infarction was closely related to syndrome of phlegm-turbid block(correlation distance was 0.01048). Conclusion: Through correspondence analysis method, it is possible to dig into the complex syndrome system of TCM. Suggesting that dyslipidemia combined with coronary heart disease can be supplemented with products for invigorating the spleen and qi. With hypertension, attention should be paid to promoting blood circulation and removing phlegm. With type 2 diabetes, combined with qi and stasis prescription drugs. With cerebral infarction to resolve phlegm.