腮腺转移性恶性肿瘤的预后因素分析

Prognostic factors of metastatic malignant tumor of parotid gland

目的:探讨腮腺转移性恶性肿瘤的临床特点及预后因素。方法:回顾性分析2008年1月~2021年2月于北京协和医院行腮腺肿瘤活检或腮腺肿瘤切除的患者资料,按拟定诊断标准,筛选出经病理证实为腮腺转移性恶性肿瘤的患者共32例,并用生存分析模型对预后进行分析。结果:32例腮腺转移性恶性肿瘤患者肿瘤原发部位面颈部者占比81.25%。32例患者中位生存期为27个月,3年和5年累积生存率分别为59.7%和47.5%。经Kaplan-Meier及Cox生存分析原发部位(P=0.011),腮腺肿瘤直径(P<0.001),是否根治(P=0.017)为独立预后因素。结论:原发部位、腮腺肿瘤直径,是否根治为影响腮腺转移性恶性肿瘤患者预后的独立因素。及早诊断和治疗,有利于延长患者生存期。

Objective:To investigate the clinical characteristics and prognostic factors of metastatic malignant tumors of parotid gland.Methods:From January 2008 to February 2021,the data of patients underwent parotid gland tumor biopsy or parotid gland tumor resection in Peking Union Medical College Hospital were retrospectively analyzed.According to the established diagnostic criteria,32 patients with pathologically confirmed metastatic malignant tumor of parotid gland were selected,and the prognosis was analyzed by survival analysis model.Results:Totally 81.25%of the 32 patients whose primary tumor site was face and neck.The median survival time of the 32 patients was 27 months,and the 3-year and 5-year cumulative survival rates were 59.7%and 47.5%respectively.Kaplan-Meier and Cox survival analysis showed that the following were independent prognostic factors,primary location(P=0.011),parotid tumor diameter(P<0.001),whether radical treatment(P=0.017).Conclusion:Primary location,parotid tumor diameter,whether radical treatment or not are independent prognostic factors for patients with metastatic parotid tumor.Early diagnosis and treatment is conducive to prolong the survival of patients.