盐酸羟考酮注射液在舌癌根治术留置气管导管患者术后镇痛中的应用效果

Effect of oxycodone hydrochloride injection on postoperative analgesia in patients with indwelling tracheal catheter after radical tongue carcinoma

目的:探讨盐酸羟考酮注射液在舌癌根治术留置气管导管患者术后镇痛中的应用效果。方法:选取全麻下行舌癌根治术且术后留置气管导管患者84例,根据术后镇痛药物的不同,随机分为研究组(羟考酮,Q组)和对照组(舒芬太尼,S组),每组各42例。比较两组患者术后2、6、12、24、48 h不同时点的视觉模拟评分(VAS),每小时呛咳反应及生命体征变化,同时记录并发症发生率。结果:术后,两组患者的VAS评分随时间推移均逐步下降;Q组在术后12、24、48 h时间点的VAS评分均低于S组(P<0.05),但两组术后2 h、6 h时间点VAS评分无统计学差异(P>0.05)。Q组平均每小时呛咳次数少于S组(P<0.05)。两组患者术后各时间点的生命体征变比较,差异无统计学意义(P>0.05);不良反应事件中,Q组恶心呕吐发生率低于S组(P<0.05),而其他不良反应(呼吸抑制、头晕、尿潴留、瘙痒)的发生率无显著性差异(P>0.05)。结论:盐酸羟考酮注射液能有效缓解舌癌根治术患者术后疼痛,明显改善留置气管导管所致的呛咳反应,并减少了恶心呕吐的发生,效果优于舒芬太尼。

Objective:To investigate the effect of oxycodone hydrochloride injection on postoperative analgesia in patients with tongue cancer undergoing radical surgery with Indwelling endotracheal tube.Methods:A total of 84 patients with tongue cancer undergoing radical surgery under general anesthesia and endotracheal catheter indwelling after surgery were randomly divided into study group(oxycodone,Q group)and control group(sufentanil,S group)according to different postoperative analgesics,with 42 cases in each group.Visual analogue scale(VAS),hourly cough response and vital signs changes were compared between 2 groups at different time points 2,6,12,24 and 48 h after surgery,and the incidence of complications was recorded.Results:Postoperative VAS scores of the two groups gradually decreased over time,and compared between the two groups,VAS scores of the Q group at 12,24 and 48 h after surgery were lower than those of the S group(P<0.05),but there was no statistical difference between the two groups at 2 h and 6 h after surgery(P>0.05).The average number of choking cough per hour in group Q was less than that in group S(P<0.05).There was no statistical significance in the changes of vital signs at each postoperative time point between 2 groups(P>0.05).Among the adverse events,the incidence of nausea and vomiting in group Q was lower than that in group S(P<0.05),while there was no significant difference in the incidence of other adverse events(respiratory depression,dizziness,urinary retention and pruritus)(P>0.05).Conclusion:Oxycodone hydrochloride injection can effectively relieve postoperative pain in patients with radical tongue cancer,significantly improve the cough response caused by indwelling tracheal tube,and reduce the incidence of nausea and vomiting,the effect is better than sufentanil.