细菌群体通讯信号及其淬灭研究进展

Progress in quorum sensing signals and their quenching of bacteria

群体感应(Quorum sensing,QS)是细菌通过信号分子的分泌、识别,从而调控细胞运动性、生物膜形成、毒素产生等致病行为的细胞交流机制,是病原菌致病过程的指挥系统,也是细菌病害防控的新靶标.群体感应淬灭(Quorum quenching,QQ)则是通过信号分子类似物、信号分子降解酶剂、信号受体激活剂/抑制剂等策略干扰、阻断病原菌的群体感应通讯系统.文章综述了3类重要的细菌群体通讯信号及其淬灭研究的进展,并对研究进行了总结与展望.

Quorum sensing(QS)is the cell-cell communication mechanism in bacteria to regulate cell motility,biofilm formation,toxin production and other pathogenic behaviors via signal molecules secretion and recognition.QS is essential for many pathogenic bacteria to regulate virulence genes expression to invade their hosts,which makes it as a very attractive target for the development of novel disease-suppressive strategies.Quorum quenching(QQ)is to interfere and block the expression of pathogenic related genes modulated by the quorum sensing of bacteria through signal molecule analogues,signal molecule degrading enzymes and signal receptor activators/inhibitors.This paper reviews the research progress of three important bacterial communication signals and their quenching,and summarizes and prospects the research.