全国住院输血新生儿血常规检测指标分析

Analysis of Blood Routine Indexes of Hospitalized Newborns with Blood Transfusion in China

目的调查分析全国住院输血新生儿血常规检测指标,为深入研究不同胎龄新生儿血常规参考范围提供数据支持。方法收集全国5669例住院输血新生儿基本信息,并按照出生胎龄分为<32 w组、32~36 w组、≥37 w组,采集输血前三组不同胎龄新生儿血常规指标数据,对检测结果进行汇总分析。结果不同胎龄组内新生儿红细胞计数、红细胞比容及血红蛋白随着日龄增加而降低,红细胞计数在出生第0天、1~2天、6~7天、9~10天组间比较差异有统计学意义,其他日龄组间差异无统计学意义。红细胞比容和血红蛋白在出生第0~1天、1~2天、3~4天组间比较差异有统计学意义,其他日龄组间差异无统计学意义。不同胎龄组内新生儿白细胞计数随着日龄增加而降低,在出生第0~1天、1~2天、2~3天、3~4天、6~7天、8~9天、≥16天组间差异有统计学意义,其他日龄组间差异无统计学意义。不同胎龄组内新生儿血小板计数从出生后0~1天到≥16天均有明显的升高,在出生第0~1天、1~2天、7~9天、11~14天、≥16天组间比较差异有统计学意义,其他日龄组间差异无统计学意义。结论住院输血新生儿血常规指标变化明显,依据不同胎龄日龄制定新生儿血常规参考范围对新生儿精准诊疗意义重大。

Objective To explore the blood routine index reference value of hospitalized newborns with blood transfusion throughout the country and to provide data support for blood routine reference range of newborns in different gestational ages.Methods The basic information of 5669 hospitalized newborns with blood transfusion were collected and divided into three groups according to their gestational age:<32 w group,32~36 w group and≥37 w group.The data of blood routine indexes of newborns in different gestational ages before blood transfusion were collected and analyzed.Results The erythrocyte count,the hematocrit and the hemoglobin of newborns in different gestational age groups decreased with the increase of postnatal days.There were statistical differences in the erythrocyte count of newborns on the day 0,1~2,6~7 and 9~10,but there were no differences among other time groups.The hematocrit and the hemoglobin of newborns in different gestational age groups decreased with the increase of postnatal days.There were statistical differences in hematocrit and hemoglobin among groups on the day 0~1,1~2 and 3~4,but there were no differences among other groups.The white blood cell count of newborns in different gestational age groups decreased with the increase of postal days,and there were statistical differences among groups on day 0~1,1~2,2~3,3~4,6~7,8~9 and≥16 d,but no differences among other groups.The platelet count of newborns in different gestational age groups increased obviously from day 0~1 to≥16 after birth.There were statistical differences in platelet count among groups on day 0~1,1~2,7~9,11~14 and≥16 after birth,but there were no differences among other groups.Conclusion The changes of blood routine indexes in newborns with blood transfusion are significant,and it is helpful to guide clinical diagnosis and precise treatment to formulate the reference range of blood routine according to gestational age and postnatal days.