摘要
过氧化物氧还原蛋白酶(peroxiredoxin 1,Prdx1)作为普遍存在且高度保守的抗氧化蛋白超家族成员,在哺乳动物中含量最高且组织分布最广泛,是最受关注的抗氧化因子之一。Prdx1是一种抗氧化剂,同时兼具分子伴侣的功能,广泛参与体内各器官、细胞的抗氧化应激过程。人体疾病的进展过程中普遍存在炎症,Prdx1在神经系统、消化系统、循环系统及呼吸系统等炎症性疾病以及感染性疾病的发生发展过程中扮演重要角色。
As a ubiquitous and highly conserved member of the antioxidant protein superfamily, peroxiredoxin 1(Prdx1) has the highest content and the most extensive tissue distribution in mammals and is one of the most concerned antioxidant factors. Prdx1 is an antioxidant and has the function of molecular chaperones, which makes it widely involved in the process of anti-oxidative stress in various organs and cells in the body. Inflammation is commonly involved in the progression of human diseases. Prdx1 plays important role in the occurrence and development of inflammatory diseases in the nervous system, digestive system, circulatory system, and respiratory system, and of infectious diseases.
作者
胡成云(综述)
张哲弢(综述)
唐朝亮(审校)
HU Chengyun;ZHANG Zhetao;TANG Chaoliang(Wannan Medical College,Wuhu Anhui 241002;Department of Anesthesiology,First Affiliated Hospital of University of Science and Technology of China,Hefei 230001;Department of Pharmacy,First Affiliated Hospital of University of Science and Technology of China,Hefei 230036,China)
出处
《临床与病理杂志》
CAS
2022年第3期731-737,共7页
Journal of Clinical and Pathological Research
基金
国家自然科学基金(81801175)
中国博士后科学基金(2019M662179)
安徽省博士后研究人员科研活动经费(2019B324)
中央高校基本科研业务费专项资金(WK9110000044)。
关键词
Prdx1
炎症
活性氧
氧化应激
peroxiredoxin 1
inflammation
reactive oxygen species
oxidative stress
