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外泌体产生的生物学效应对眼部疾病的作用及治疗应用 被引量:1

Role of biological effects produced by exosomes on ophthalmopathy and its therapeutic application
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摘要 外泌体是由细胞分泌的一种纳米级盘状囊泡,天然包含有蛋白质、复杂RNA和脂类等“货物”,并广泛存在于生物组织与体液中,可通过血液、唾液、脑脊液乃至泪液等体液将这些具有生物活性的物质输送到附近的或远距离的细胞中,以此对受体细胞产生不同调节作用。外泌体的功能多种多样,可以参与到机体的细胞迁移与分化、抗原提呈、免疫应答、肿瘤侵袭等等方面,而定义它们的一个变量就是其细胞来源。本文总结了来源于几种不同细胞分泌的外泌体在眼部疾病中的有利性或有害性,并展望了外泌体未来在眼病中进行早期诊断和治疗方面的潜力。 Exosomes are nanoscale discoid vesicles secreted by cells,which naturally contain“goods”such as proteins,complex RNA and lipids,and are widely found in biological tissues and body fluids.These bioactive substances can be transported to nearby or distant cells through body fluids such as blood,saliva,cerebrospinal fluid and even tears,thus having different regulatory effects on receptor cells.Exosomes have a variety of functions,which can be involved in cell migration and differentiation,antigen presentation,immune response,tumor invasion and so on,and one of the variables that define them is their cell source.This review summarizes the advantages or disadvantages of exosomes secreted by several different cells under ophthalmatic pathological conditions,and provides prospective views regarding the potential role of exosomes in early diagnosis and treatment of ophthalmopathy in the future.
作者 李映雪 付燕 童瑶 杨路 Li Yingxue;Fu Yan;Tong Yao;Yang Lu(Department of Ophthalmology,The Affiliated of School of Medicine of Ningbo University;Department of Ophthalmology,The Affiliated People’s Hospital of Ningbo University,Ningbo 315000,China)
出处 《中国组织化学与细胞化学杂志》 CAS CSCD 2021年第6期602-607,共6页 Chinese Journal of Histochemistry and Cytochemistry
基金 省医药卫生面上项目A类(2019KY193)。
关键词 外泌体 细胞外囊泡 视网膜色素上皮细胞 间充质干细胞 新生血管 免疫调节 Exosome extracellular vesicle retinal pigment epithelium cell mesenchymal stem cell neovascularization immunomodulatory
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