急性脑梗塞介入治疗与静脉溶栓治疗的效果观察及安全性分析

Effect and safety analysis of interventional therapy and intravenous thrombolytic therapy for acute cerebral infarction

目的:探讨为急性脑梗塞患者开展介入治疗与静脉溶栓联合治疗干预的临床效果。方法:依据入院时间顺序将2019年1月至2020年12月期间于本院接受治疗的70例急性脑梗塞患者分别平均纳入对照组和观察组,每组各35例。对照组单纯给予静脉溶栓治疗干预,观察组联合开展静脉溶栓及介入治疗干预。对比两组治疗后的神经功能改善情况、血清学相关指标水平及预后恢复效果。结果:治疗前,两组的神经功能评分相比无明显差异(P>0.05);治疗后,两组的神经功能评分均低于治疗前,且观察组的神经功能评分(10.41±1.04)低于对照组(P<0.05)。治疗前,两组的各项血清学相关指标的结果数值相比均无明显差异(P>0.05);治疗后,两组的各项血清学相关指标的结果数值均低于治疗前,且观察组的神经元特异性烯醇化酶(10.34±1.45)μg/L、神经生长因子(95.47±11.05)ng/mL及脑钠肽(160.46±14.51)ng/L,检验结果数值均低于对照组(P<0.05)。治疗后,两组的死亡率及颅内出血发生率相比均无明显差异(P>0.05)。结论:为急性脑梗塞患者联合开展介入治疗与静脉溶栓治疗干预的效果较为显著,可明显改善神经功能受损情况及血清学相关指标,同时可避免增加死亡及颅内出血表现,值得进行推广应用。

Objective:To investigate the clinical effect of interventional therapy combined with intravenous thrombolytic therapy in patients with acute cerebral infarction.Methods:According to the time order of admission,70 patients with acute cerebral infarction treated in our hospital from January 2019 to December 2020 were equally included in the control group and the observation group,with 35 patients in each group.The control group was treated with intravenous thrombolytic therapy,and the observation group was treated with intravenous thrombolytic therapy and interventional therapy.The improvement of neurological function,serological indicators and prognosis were compared between the two groups after treatment.Results:Before treatment,there was no significant difference in neurological function scores between the two groups(P>0.05).After treatment,the neurological function score of both groups was lower than before,and the neurological function score of observation group(10.41±1.04) was lower than that of control group(P<0.05).Before treatment,there were no significant differences in the results and values of serology-related indexes between the two groups(P>0.05).After treatment,the results of serological indicators in both groups were lower than before,and the neuron specific enolase(10.34±1.45)μg/L,nerve growth factor(95.47±11.05) ng/mL and brain natriuretic peptide(160.46±14.51) ng/L in the observation group.The test results were lower than those of the control group(P<0.05).After treatment,there were no significant differences in mortality and incidence of intracranial hemorrhage between 2 groups(P>0.05).Conclusion:Combined interventional therapy and intravenous thrombolytic therapy for patients with acute cerebral infarction has a significant effect,which can significantly improve neurological impairment and serological indicators,and avoid increased death and intracranial hemorrhage,which is worthy of promotion and application.