胰高血糖素样肽-1对心血管系统的保护作用

Protective effect of glucagon like peptide-1 on cardiovascular system

随着社会发展及人均寿命延长,我国糖尿病患者逐年增多,心血管病发病率也呈逐年上升趋势。据统计心血管病是全球范围内导致人类死亡的主要原因之一。糖尿病作为独立危险因子,会影响到心血管病发病率,威胁患者生命安全。因此在治疗糖尿病的同时因做好心血管病的相关预防工作。胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是近年来治疗糖尿病的新型药物,GLP-1的相关生物学效应研究中,最先发现的是其促进胰岛素分泌的作用,且伴有葡萄糖依赖性。在机体进食后体内的GLP-1分泌会有所增加,进而影响胰岛素的分泌,能够帮助缓解血糖情况,血糖的范围处于正常时就不会影响胰腺来促进分泌,研究GLP-1对心血管的保护作用具有研究价值。本研究对近年来GLP-1对心血管系统的保护作用研究情况进行综述。

With the development of society and the prolongation of life expectancy,the number of diabetic patients has increased year by year,and the incidence rate of cardiovascular diseases has been increasing year by year.According to statistics,cardiovascular disease is one of the main causes of human death worldwide.Diabetes mellitus as an independent risk factor will affect the incidence rate of cardiovascular disease and threaten the safety of patients.Therefore,in the treatment of diabetes at the same time to do a good job in cardiovascular disease prevention.Glucagon like peptide-1(Glucagon-like peptide-1,GLP-1) is a new drug for the treatment of diabetes in recent years.In the study of biological effects of GLP-1,the first discovery is its role in promoting insulin secretion,accompanied by glucose dependence.The secretion of GLP-1 in the body will increase after eating,which will affect the secretion of insulin and help alleviate blood glucose.When the range of blood glucose is normal,it will not affect the pancreas to promote secretion,It is valuable to study the protective effect of GLP-1 on cardiovascular system.This study reviews the protective effect of GLP-1 on cardiovascular system in recent years.