血清CA724、PGⅠ、PGⅡ、G-17在胃癌不同时期的表达情况及与术后感染、复发的关系

The expression of serum CA724,PGⅠ,PGⅡ,G-17 in different stages of gastric cancer and their relationships with postoperative infection and recurrence

目的分析血清糖类抗原(CA)724、胃蛋白酶原(PG)Ⅰ、PGⅡ、胃泌素-17(G-17)在胃癌不同时期的表达情况及其与术后感染、复发的关系。方法选择2019年6月至2021年5月西安高新医院收治的80例进行手术治疗的胃癌患者为胃癌组,同期西安高新医院80例体检健康者纳入对照组。检测所有研究对象血清CA724、PGⅠ、PGⅡ、G-17水平,比较胃癌组与对照组血清CA724、PGⅠ、PGⅡ、G-17水平,比较胃癌组内不同阶段,以及术后有无感染、有无复发患者间血清CA724、PGⅠ、PGⅡ、G-17水平。结果胃癌组血清CA724、PGⅡ、G-17水平明显高于对照组,PGⅠ水平明显低于对照组,差异有统计学意义(P<0.05)。胃癌组内进展期患者血清CA724、PGⅡ、G-17水平明显高于早期胃癌患者,PGⅠ水平明显低于早期胃癌患者,差异有统计学意义(P<0.05);术后复发、感染患者血清PGⅠ、PGⅡ、G-17水平分别明显高于术后未复发、未感染患者,差异有统计学意义(P<0.05);术后复发患者血清CA724水平明显高于术后未复发患者,差异有统计学意义(P<0.05)。血清PGⅠ、PGⅡ、G-17水平为术后感染、术后复发的影响因素(P<0.05)。CA724为术后复发的影响因素(P<0.05)。结论CA724、PGⅠ、PGⅡ、G-17在胃癌与体检健康者、进展期与早期胃癌患者血清表达水平有明显差异,且其表达水平与术后感染、复发关系密切,可用于术后感染诊断及预后评估。

Objective To analyze the expression of serum carbohydrate antigen(CA)724,pepsinogen(PG)Ⅰ,PGⅡ,gastrin-17(G-17)in different stages of gastric cancer and their relationships with postoperative infection and recurrence.Methods A total of 80 patients with gastric cancer who received surgical treatment in Xi'an High-tech Hospital from June 2019 to May 2021 were selected as the gastric cancer group,80 healthy persons in Xi'an High-tech Hospital during the same period were included in the control group.Serum levels of CA724,PGⅠ,PGⅡ and G-17 were detected in all subjects.Serum levels of CA724,PGⅠ,PGⅡ and G-17 were compared between gastric cancer group and control group.Serum levels of CA724,PGⅠ,PGⅡ and G-17 were compared in patients with different stages,with or without postoperative infection,with or without recurrence.Results The levels of serum CA724,PGⅡ and G-17 in gastric cancer group were significantly higher than those in control group,while the level of PGⅠ was lower than that in control group,the differences were statistically significant(P<0.05).The levels of serum CA724,PGⅡ and G-17 in patients with advanced gastric cancer were significantly higher than those in patients with early gastric cancer,while the level of PGⅠwas lower than that in patients with early gastric cancer,the differences were statistically significant(P<0.05).The levels of serum PGⅠ,PGⅡ and G-17 in patients with recurrence and infection were significantly higher than those in patients without recurrence and without infection,the differences were statistically significant(P<0.05).The serum CA724 level in patients with recurrence was significantly higher than that in patients without recurrence,the difference was statistically significant(P<0.05).Serum PGⅠ,PGⅡ and G-17 levels were the influencing factors of postoperative infection and recurrence(P<0.05).CA724 was the influencing factor of postoperative recurrence(P<0.05).Conclusion The expression levels of CA724,PGⅠ,PGⅡ and G-17 in serum of patients with gastric cancer and healthy persons,advanced and early gastric cancer are significantly different,their levels relate closely to postoperative infection and recurrence,which could be used for the diagnosis and prognosis evaluation of postoperative infection.