全身麻醉药物对睡眠影响的研究进展

Progress in mechanisms of effects on sleep by general anesthetics

全身麻醉和睡眠状态均表现为意识的可逆性丧失,对外界刺激反应性下降,并在行为学和脑电图等方面具有一定的相似性。全身麻醉过程和睡眠状态的产生可能共享部分分子靶点和神经环路。全身麻醉药物可通过改变睡眠结构、影响昼夜节律和调控睡眠-觉醒环路等机制对睡眠产生“双面性”和“多维度”的影响。全身麻醉和睡眠机制至今尚未阐明。全文将从全身麻醉作用机制、睡眠机制以及全身麻醉药物对睡眠的影响进行综述。

General anesthesia and natural sleep are manifest as a reversible loss of consciousness,a decrease in response to external stimuli,and had some similarities in behavior,electroencephalogram and so on.Along with the neuroscience is deeply investigated,there is growing evidence that the process of general anesthesia and natural sleep may share the same mechanisms of molecular targets and neural circuits.General anesthetics have“double-sided”and“multi-dimensional”effects on sleep through changing sleep structure,affecting circadian rhythm and regulating sleep wake loop,etc.The mechanism of general anesthesia and sleep remain not thoroughly elucidated to date.This article will summarizing the latest research progress from those three aspects,including general anesthesia mechanism,sleep mechanism and the mechanisms of effects on sleep by general anesthetics.