Hcy、NF-κB、MCP-1与急性脑梗死关系的研究进展

Relationship of acute cerebral infarction with Hcy,NF-κB,and MCP-1

缺血性卒中严重危害人类健康,是我国居民死亡或致残的首要病因,其早期干预治疗对改善患者预后极为重要。溶栓和血管内治疗为血管再通最有效的治疗方式,可最大程度挽救脑缺血半暗带,但脑再灌注损伤仍不可避免。炎症机制是脑缺血再灌注损伤的关键部分,因此积极减轻过度炎性反应意义重大。大量研究显示,同型半胱氨酸(Hcy)、核因子-κB(NF-κB)、单核细胞趋化蛋白-l(MCP-1)与急性脑梗死关系密切,与脑缺血后炎症损伤联系紧密。本文就Hcy、NF-κB、MCP-1与急性脑梗死关系的研究进展作一综述,以期为减轻脑缺血再灌注损伤、改善患者预后提供新思路。

Ischemic stroke seriously endangers human health and is the primary cause of death or disability in China.The early treatment is very important for the prognosis of ischemic stroke patients.Thrombolytic and intravascular therapies are the most effective treatment for vascular recanalization,and can save cerebral ischemic penumbra to the greatest extent,but cerebral reperfusion injury is still inevitable.The mechanism of inflammatory injury is an important part of cerebral ischemia-reperfusion injury;therefore,it is of great significance to actively reduce the excessive inflammatory reaction of ischemic brain tissue.Evidences have shown that homocysteine(Hcy),nuclear factor-κB(NF-κB),and monocyte chemotactic protein-1(MCP-1)are closely related to acute cerebral infarction and inflammatory injury after ischemic stroke.This article reviews the research progress on the relationship of acute ischemic stroke with Hcy,NF-κB,and MCP-1,so as to provide new ideas for alleviating cerebral ischemia-reperfusion injury and improving the patients'prognosis.