肠内营养支持治疗在晚期胃癌转化治疗中的疗效观察

Therapeutic effect of enteral nutrition support in the transformation therapy of advanced gastric cancer

目的探讨肠内营养支持治疗在晚期胃癌转化治疗中的临床疗效。方法回顾性分析2019年9月至2021年8月浙江省人民医院收治的经转化治疗的晚期胃癌患者82例。其中观察组41例患者在常规转化治疗的基础上结合肠内营养支持治疗;对照组41例患者只进行常规的转化治疗。分别在治疗前以及3周期转化治疗结束后第7天检测两组患者的前白蛋白、血清总蛋白、白蛋白等营养相关性指标和CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)等免疫相关性指标,并对比两组患者的上述指标及转化成功率。结果两组患者治疗前的前白蛋白、血清总蛋白、白蛋白及CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)等相关指标比较差异无统计学意义(均P>0.05)。经3周期转化治疗结束后第7天,观察组患者的上述指标均高于对照组(均P<0.05)。观察组患者的转化成功率大于对照组(P<0.05)。结论晚期胃癌患者转化治疗过程中合理使用肠内营养支持治疗,可明显改善患者的营养状况和免疫功能,增加化疗耐受性,提高转化成功率。

Objective To investigate the clinical effect of enteral nutrition support in the transformation therapy of advanced gastric cancer.Methods Eighty-two patients with advanced gastric cancer treated by transformation in Zhejiang Provincial People′s Hospital from September 2019 to August 2021 were analyzed retrospectively.41 patients in the observation group were treated with enteral nutrition support on the basis of routine transformation treatment;41 patients in the control group received only routine transformation treatment.The nutritional related indexes such as prealbumin,total serum protein and albumin and immune related indexes such as CD4^(+),CD8^(+),CD4^(+)/CD8^(+)were detected before treatment and on the 7th day after the end of 3-cycle transformation treatment,and the above indexes and transformation success rate of the two groups were compared.Results There was no significant difference in prealbumin,total serum protein,albumin,CD4^(+),CD8^(+),CD4^(+)/CD8^(+)between the two groups before treatment(all P>0.05).On the 7th day after three cycles of transformation treatment,the above indexes in the observation group were higher than those in the control group,with significant difference(all P<0.05).The success rate of transformation in the observation group was higher than that in the control group(P<0.05).Conclusions The rational use of enteral nutrition support in the transformation treatment of patients with advanced gastric cancer can significantly improve the nutritional status and immune function of patients,increase the tolerance to chemotherapy and improve the success rate of transformation.