抑制素βB在鼻咽癌和肺腺癌中的表达及意义

Clinical significance and expression of inhibinβB in nasopharyngeal carcinoma and lung adenocarcinoma

目的研究抑制素βB(INHBB)在鼻咽癌和肺腺癌组织中的表达及其与临床病理特征的关系。方法回顾性收集在湖南省脑科医院(湖南省第二人民医院)经活检病理确诊的39例鼻咽癌组织和16例慢性鼻咽炎组织的石蜡标本,以及经手术切除的30例肺腺癌患者的癌组织和癌旁组织的石蜡标本,采用免疫组织化学SP法检测INHBB在鼻咽癌和肺腺癌组织中的表达,同时分析其与临床病理指标的关系。结果INHBB在鼻咽癌组织中的表达低于慢性鼻咽炎组织(51.28%vs 81.25%,P=0.039),且鼻咽癌患者的INHBB表达与淋巴转移(P=0.026)和临床分期(P=0.039)有关;INHBB在肺腺癌组织的表达水平显著高于癌旁组织(86.67%vs 23.33%,P<0.001),肺腺癌患者的INHBB的表达水平仅与临床分期(P=0.048)有关。结论INHBB的表达可能与鼻咽癌和肺腺癌疾病的进展有关,有望成为新型的诊断生物标志物。

Objective To investigate the expression of inhibinβB(INHBB)in nasopharyngeal carcinoma(NPC)and lung adenocarcinoma(LUAD)and its relationship with clinicopathological features.Methods Paraffin-embedded tissue specimens of 39 patients with NPC and 16 patients with chronic nasopharyngitis diagnosed by biopsy,and 30 patients with LUAD after surgical resection collected in Brain Hospital of Hunan Province(the Second People′s Hospital of Hunan Province)were analyzed retrospectively.The expression of INHBB in NPC and LUAD was detected by immunohistochemical streptavidin-perosidase(SP)method and the relationship of INHBB expression level with clinicopathological indicators was analyzed.Results The expression of INHBB in NPC was lower than that in chronic nasopharyngitis(51.28%vs 81.25%,P=0.039),and the expression of INHBB was related to lymph node metastasis(P=0.026)and clinical stage(P=0.039);On the contrary,the expression level of INHBB in LUAD was significantly higher than that in adjacent tissues(86.67%vs 23.33%,P<0.001).The expression level of INHBB in patients with LUAD was only related to clinical stage(P=0.048).Conclusions The expression of INHBB might play an important role in the development and progression of NPC and LUAD,and it was expected to be a novel diagnostic biomarker.