mTOR信号通路调控自噬在脊髓损伤中的作用研究进展

Research advances on the role of mTOR signaling pathway in regulating autophagy in spinal cord injury

创伤性脊髓损伤(SCI)对患者身体和心理健康具有毁灭性的影响。自噬广泛参与机体的各种生理病理过程,在脊髓损伤中发挥关键作用。雷帕霉素靶蛋白(mTOR)是自噬的主要调节因子。mTOR调控自噬与脊髓损伤病理过程关系密切,可有效促进脊髓损伤的恢复。因此,mTOR是一个很有前景的脊髓损伤治疗靶点。本文就mTOR信号转导通路调控自噬在脊髓损伤中的作用进行综述,以期为后续研究提供参考。

Traumatic spinal cord injury(SCI)has devastating effects on patients′physical and mental health.Autophagy is widely involved in various physiological and pathological processes of the body and plays a key role in spinal cord injury.The mammalian target of rapamycin(mTOR)is the main regulator of autophagy.mTOR regulation of autophagy is closely related to the pathological process of spinal cord injury,and can effectively promote the recovery of spinal cord injury.Therefore,mTOR is a promising target for treatment of spinal cord injury.This article reviews the role of mTOR signal transduction pathway in the regulation of autophagy in spinal cord injury,in order to provide reference for follow-up research.