薯蓣丸联合脐灸治疗肺癌癌因性疲乏临床研究

Clinical Study on Prescription of Shuyu Pills Combined with Umbilical Moxibustion for Cancer-Related Fatigue Due to Lung Cancer

目的:观察薯蓣丸联合脐灸治疗肺癌癌因性疲乏(CRF)的临床疗效。方法:选取80例肺癌CRF患者(气血两虚证)作为研究对象,按随机数字表法分为对照组与治疗组各40例。对照组采用常规治疗,治疗组在对照组基础上加用薯蓣丸联合脐灸治疗,2组均治疗1个月。比较2组临床疗效,观察2组治疗前后中医证候评分、癌因性疲乏量表(CFS)评分的变化。结果:治疗后,治疗组临床疗效总有效率为97.5%,对照组临床疗效总有效率为67.5%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组CFS评分均较治疗前下降(P<0.05);治疗组CFS评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组神疲乏力、少气懒言、失眠心悸、头晕目眩的中医证候评分均较治疗前下降(P<0.05);治疗组上述4项中医证候评分均低于对照组,差异均有统计学意义(P<0.05)。结论:薯蓣丸联合脐灸治疗肺癌CRF,能够改善肺癌CRF患者的临床症状,提高其生活质量。

Objective:To observe the clinical effect of prescription of Shuyu pills combined with umbilical moxibustion for cancer-related fatigue(CRF)due to lung cancer.Methods:A total of 80 cases of CRF patients with lung cancer with dual deficiency of qi and blood syndrome were selected as the study subjects and divided into the control group and the treatment group according to the random number table method,with 40 cases in each group.The control group was given routine treatment,and the treatment group was additionally treated with prescription of Shuyu pills combined with umbilical moxibustion based on the treatment of the control group.Both groups were treated for one months.The clinical effects in the two groups were compared.Before and after treatment,the changes in scores of Chinese medicine syndromes and Cancer Fatigue Scale(CFS)in the two groups were observed.Results:After treatment,the total effective rate of clinical effect was 97.5% in the treatment group and 67.5% in the control group,the difference being significant(P<0.05).After trewatment,the CFS scores in the two groups were decreased when compared with those before treatment(P<0.05);the CFS score in the treatment group was lower than that in the control group,the difference being significant(P<0.05).After treatment,Chinese medicine syndrome scores including tiredness,short breath and lazy to talk,insomnia and palpitation,and dizziness and dizzy vision in the two groups were decreased when compared with those before treatment(P<0.05);the above four Chinese medicine syndrome scores in the treatment group were lower than those in the control group,differences being significant(P<0.05).Conclusion:Prescription of Shuyu pills combined with umbilical moxibustion for patients with CRF due to lung cancer can improve their clinical symptoms and quality of life.