摘要
目的:观察麝香保心丸联合美托洛尔治疗老年冠心病稳定性心绞痛的临床疗效。方法:选取133例老年冠心病稳定性心绞痛患者为研究对象,按随机数字表法分为观察组68例和对照组65例。2组均依据冠心病二级防治方案,给予降血脂、抗血小板、抗心肌缺血类药治疗;对照组加用琥珀酸美托洛尔口服,观察组在对照组的基础上联合麝香保心丸治疗。观察2组临床治疗效果,心绞痛发作次数、硝酸甘油使用量及血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果:观察组改善心绞痛总有效率为94.12%,心电图总有效率为86.76%,对照组分别为72.31%、64.62%,2组比较,差异均有统计学意义(P<0.05)。治疗前,2组心绞痛发作次数、硝酸甘油使用量比较,差异无统计学意义(P>0.05);治疗后,2组心绞痛发作次数、硝酸甘油使用量均较治疗前减少(P<0.05),且观察组心绞痛发作次数、硝酸甘油使用量均少于对照组(P<0.05)。治疗前,2组TG、TC、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05)。治疗后,2组TG、TC、LDL-C水平低于治疗前,HDL-C水平高于治疗前(P<0.05),且观察组上述血脂指标改善较对照组更显著(P<0.05)。结论:麝香保心丸配合美托洛尔治疗老年冠心病稳定性心绞痛疗效显著,能减少患者心绞痛发作次数和硝酸甘油使用量,显著改善血脂水平。
Objective:To observe the clinical effect of Shexiang Baoxin pills combined with metoprolol for stable angina pectoris of coronary heart disease in senile patients.Methods:A total of 133 cases of senile patients with stable angina pectoris of coronary heart disease were selected as the research objects and were divided into the observation group and the control group according to the random number table method,with 68 and 65 cases in each group respectively.Both groups were treated according to the secondary prevention and treatment plan of coronary heart disease,and were given lipidlowering drugs,antiplatelet drugs and anti-myocardial ischemia drugs;the control group was additionally given the oral administration of metoprolol succinate,and the observation group was additionally treated with Shexiang Baoxin pills based on the treatment of the control group.The clinical effects,the onset frequency of angina pectoris,the amount of nitroglycerin usage,and the levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) in serum in the two groups were observed.Results:The total effective rates of angina pectoris and electrocardiogram were 94.12% and 86.76% respectively in the observation group,and 72.31% and64.62% respectively in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the onset frequency of angina pectoris and the amount of nitroglycerin usage between the two groups(P>0.05).After treatment,the onset frequency of angina pectoris and the amount of nitroglycerin usage in the two groups were decreased when compared with those before treatment(P<0.05),and the onset frequency of angina pectoris and the amount of nitroglycerin usage in the observation group were less than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of TG,TC,LDL-C and HDL-C between the two groups(P>0.05).After treatment,the levels of TG,TC and LDL-C in the two groups were lower than those before treatment,and the levels of HDL-C were higher(P<0.05);the improvement of the above blood lipid indexes in the observation group was more significant than that in the control group(P<0.05).Conclusion:The therapy of Shexiang Baoxin pills combined with metoprolol for stable angina pectoris of coronary heart disease in senile patients,and can reduce the onset frequency of angina pectoris and the amount of nitroglycerin usage,and significantly improve the levels of blood lipid.
作者
潘方瑛
范晓涛
黄丙勇
PAN Fangying;FAN Xiaotao;HUANG Bingyong
出处
《新中医》
CAS
2022年第4期43-46,共4页
New Chinese Medicine
关键词
冠心病
老年人
稳定性心绞痛
麝香保心丸
琥珀酸美托洛尔
血脂代谢
Coronary heart disease
The aged
Stable angina pectoris
Shexiang Baoxin pills
Metoprolol succinate
Blood lipid metabolism