早期停育胚胎组织Bcl-2、c-Myc癌基因和P53、P16抑癌基因的表达

Expression of Bcl-2 and c-Myc oncogenes and P53 and P16 anti-oncogenes in early development-arrest-embryo tissue

目的:探索早期停育胚胎组织与正常发育的早期胚胎组织癌基因、抑癌基因表达差异。方法:应用免疫组化法分析56例早期正常发育清宫的胚胎组织和68例早期停育胚胎组织Bcl-2、c-Myc癌基因及P53、P16抑癌基因表达差异。结果:Bcl-2、c-Myc癌基因在早期正常发育清宫的胚胎组织和早期停育胚胎组织中的阳性率分别为53.57%(30/56)、30.36%(17/56)和77.94%(53/68)、45.59%(31/68);P53、P16抑癌基因在早期正常发育清宫的胚胎组织和早期停育胚胎组织中的阳性率分别为39.29%(22/56)、73.21%(41/56)和27.94%(19/68)、47.06%(32/68)。结论:癌基因、抑癌基因在调控早期胚胎分化发育过程中起重要作用。

Objective:To explore the differential expression of oncogenes and anti-oncogenes in early development-arrest-embryo tissue and normal early embryonic tissue.Methods:The expression of Bcl-2 and c-Myc oncogenes and P53 and P16 anti-oncogenes in chorionic tissue were analyzed by immunohistochemical method from 56 cases of normal early embryonic tissue and 68 cases of early development-arrest-embryo tissue.Results:The positive rates of Bcl-2 and c-Myc oncogenes in normal early embryonic tissue and early development-arrest-embryo tissue were 53.57%(30/56)vs.30.36%(17/56)and 77.94%(53/68)vs.45.59%(31/68)respectively.The positive rates of P53 and P16 anti-oncogenes in normal early embryonic tissue and early development-arrest-embryo tissue were 39.29%(22/56)vs.73.21%(41/56)and 27.94%(19/68)vs.47.06%(32/68)respectively.Conclusion:The balanced expression of oncogenes and anti-oncogenes plays an important role in early embryonic development.